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dc.contributor.author
Esposito, Isabella
dc.contributor.author
Marciano, Sebastián
dc.contributor.author
Haddad, Leila
dc.contributor.author
Galdame, Omar
dc.contributor.author
Franco, Alejandra
dc.contributor.author
Gadano, Adrián Carlos
dc.contributor.author
Flichman, Diego Martin
dc.contributor.author
Trinks, Julieta
dc.date.available
2019-10-31T15:04:06Z
dc.date.issued
2019-01-21
dc.identifier.citation
Esposito, Isabella; Marciano, Sebastián; Haddad, Leila; Galdame, Omar; Franco, Alejandra; et al.; Prevalence and factors related to natural resistance-associated substitutions to direct-acting antivirals in patients with genotype 1 hepatitis C virus infection; MDPI AG; Viruses; 11; 1; 21-1-2019; 1-18
dc.identifier.issn
1999-4915
dc.identifier.uri
http://hdl.handle.net/11336/87730
dc.description.abstract
This study aimed to assess the prevalence of natural resistance-associated substitutions (RASs) to NS3, NS5A and NS5B inhibitors in 86 genotype 1 Hepatitis C Virus (HCV)-infected patients from Buenos Aires, Argentina, and to determine their effect on therapy outcome. Additionally, virological, clinical and host genetic factors were explored as predictors of the presence of baseline RASs. NS3 RASs (39.2%) were more prevalent than NS5A RASs (25%) and NS5B RASs (8.9%). In the three regions, the frequencies of RASs were significantly higher in HCV-1b than in HCV-1a. The prevalence of Y93H, L159F and Q80K were 1.3%, 6.3% and 2.5%, respectively. IFNL3 CC genotype was identified as an independent predictor of the presence of baseline RASs in NS5A and NS3 genes (p = 0.0005 and p = 0.01, respectively). Sustained virologic response was achieved by 93.3% of the patients after receiving direct-acting antivirals (DAAs), although 48.7% of them showed baseline RASs related to the DAA-regimen. Notably, the prevalence of clinically relevant RASs in the three genes was lower than that observed around the world. The baseline presence of RASs in both subtypes did not appear to affect therapy outcome. These results support the need to evaluate resistance patterns in each particular country since RASs´ prevalence significantly vary worldwide.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI AG
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DIRECT-ACTING ANTIVIRALS
dc.subject
HEPATITIS C VIRUS
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QUASISPECIES
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RESISTANCE-ASSOCIATED SUBSTITUTIONS
dc.subject.classification
Gastroenterología y Hepatología
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Prevalence and factors related to natural resistance-associated substitutions to direct-acting antivirals in patients with genotype 1 hepatitis C virus infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T18:37:51Z
dc.journal.volume
11
dc.journal.number
1
dc.journal.pagination
1-18
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Esposito, Isabella. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Marciano, Sebastián. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Haddad, Leila. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Galdame, Omar. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Franco, Alejandra. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Gadano, Adrián Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.description.fil
Fil: Flichman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.description.fil
Fil: Trinks, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.journal.title
Viruses
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/11/1/3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356817/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3390/v11010003
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