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dc.contributor.author
Azcona, Pamela Liliana
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dc.contributor.author
López Corral, Ignacio
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dc.contributor.author
Lassalle, Verónica Leticia
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dc.date.available
2019-10-28T19:49:36Z
dc.date.issued
2018-01
dc.identifier.citation
Azcona, Pamela Liliana; López Corral, Ignacio; Lassalle, Verónica Leticia; Fabrication of folic acid magnetic nanotheranostics: An insight on the formation mechanism, physicochemical properties and stability in simulated physiological media; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 537; 1-2018; 185-196
dc.identifier.issn
0927-7757
dc.identifier.uri
http://hdl.handle.net/11336/87415
dc.description.abstract
Nanodevices based on magnetite functionalized with folic acid (FA) with improved properties to be employed as theranostics in various types of cancer are here proposed. Two methodologies for FA incorporation were explored aiming to reach suitable loading efficiency as well as adequate stability of nanosystems in physiological media. To this end, simple adsorption and covalent binding of FA and some experimental conditions derived from both procedures were studied. A thorough physicochemical characterization was performed using all the formulations. The mechanism of the interaction between FA and magnetite nanoparticles (MNPs) was elucidated from characterization results supported by theoretical studies using spin-polarized density functional theory (DFT). Both data coincide in that the selective functional group of FA (pteridine group) remained available after FA binding MNPs. Such studies also demonstrated that any of FA carboxylate groups could be available to potentially link other molecule (i.e therapeutic agents). Besides, other issues that are not normally accomplished in reported articles were included; i.e the stability according to two different criteria: size evolution (expressed as hydrodynamic diameter) as a function of time in aqueous media; and the capacity FA retention in PBS, pH = 7.4. Recovered data indicated that the samples are stable at least 15 days in water and 4 h in buffer without significant modifications of their properties. The feasibility of these formulations to interact with simulated physiological fluid was also assayed. The results revealed that protein corona was formed around all the tested formulations leading to more stable nanodevices in terms of their hydrodynamic sizes and size evolution along the time. To complete the theranostic characteristic, Doxorubicin was added to the MNPs@FA by physical adsorption, to provide the therapeutic function. The satisfactory incorporation was verified by FTIR spectroscopy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BOVINE SERUM ALBUMIN
dc.subject
COVALENT LINKAGE
dc.subject
FOLIC ACID
dc.subject
MAGNETIC NANOPARTICLES
dc.subject
SIMPLE ADSORPTION
dc.subject
THERANOSTICS
dc.subject.classification
Química Inorgánica y Nuclear
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Fabrication of folic acid magnetic nanotheranostics: An insight on the formation mechanism, physicochemical properties and stability in simulated physiological media
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T20:15:41Z
dc.journal.volume
537
dc.journal.pagination
185-196
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Azcona, Pamela Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: López Corral, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.journal.title
Colloids and Surfaces A: Physicochemical and Engineering Aspects
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927775717309172
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.colsurfa.2017.10.025
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