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Artículo

Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients

Sundblad, VictoriaIcon ; Quintar, Amado AlfredoIcon ; Morosi, Luciano GastónIcon ; Niveloni, Sonia I.; Cabanne, Ana; Smecuol, Edgardo; Mauriño, Eduardo; Mariño, Karina ValeriaIcon ; Bai, Julio C.; Maldonado, Cristina AliciaIcon ; Rabinovich, Gabriel AdriánIcon
Fecha de publicación: 03/2018
Editorial: Frontiers Media S.A.
Revista: Frontiers in Immunology
ISSN: 1664-3224
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. Through interaction with a wide range of glycosylated receptors bearing complex branched N-glycans and core 2-O-glycans, these endogenous lectins trigger distinct signaling programs thereby controling immune cell activation, differentiation, recruitment and survival. Given the unique features of mucosal inflammation and the differential expression of galectins throughout the gastrointestinal tract, we discuss here key findings on the role of galectins in intestinal inflammation, particularly Crohn´s disease, ulcerative colitis, and celiac disease (CeD) patients, as well as in murine models resembling these inflammatory conditions. In addition, we present new data highlighting the regulated expression of galectin-1 (Gal-1), a proto-type member of the galectin family, during intestinal inflammation in untreated and treated CeD patients. Our results unveil a substantial upregulation of Gal-1 accompanying the anti-inflammatory and tolerogenic response associated with gluten-free diet in CeD patients, suggesting a major role of this lectin in favoring resolution of inflammation and restoration of mucosal homeostasis. Thus, a coordinated network of galectins and their glycosylated ligands, exerting either anti-inflammatory or proinflammatory responses, may influence the interplay between intestinal epithelial cells and the highly specialized gut immune system in physiologic and pathologic settings.
Palabras clave: CELIAC DISEASE , GALECTIN-1 , GALECTINS , GLYCANS , GUT INFLAMMATION , INFLAMMATORY BOWEL DISEASE
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/87379
URL: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00379/full
DOI: http://dx.doi.org/10.3389/fimmu.2018.00379
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Sundblad, Victoria; Quintar, Amado Alfredo; Morosi, Luciano Gastón; Niveloni, Sonia I.; Cabanne, Ana; et al.; Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients; Frontiers Media S.A.; Frontiers in Immunology; 9; MAR; 3-2018
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