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dc.contributor.author
Gonzalez, Susana Laura
dc.contributor.author
Meyer, Laurence
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Raggio, María Celeste
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Taleb, Omar
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Coronel, Maria Florencia
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Patte Mensah, Christine
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Mensah-Nyagan, Ayikoe Guy
dc.date.available
2019-10-28T00:24:08Z
dc.date.issued
2018-09-30
dc.identifier.citation
Gonzalez, Susana Laura; Meyer, Laurence; Raggio, María Celeste; Taleb, Omar; Coronel, Maria Florencia; et al.; Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective; Springer/Plenum Publishers; Cellular And Molecular Neurobiology.; 39; 4; 30-9-2018; 523-537
dc.identifier.issn
0272-4340
dc.identifier.uri
http://hdl.handle.net/11336/87375
dc.description.abstract
In the last decades, an active and stimulating area of research has been devoted to explore the role of neuroactive steroids in pain modulation. Despite challenges, these studies have clearly contributed to unravel the multiple and complex actions and potential mechanisms underlying steroid effects in several experimental conditions that mimic human chronic pain states. Based on the available data, this review focuses mainly on progesterone and its reduced derivative allopregnanolone (also called 3α,5α-tetrahydroprogesterone) which have been shown to prevent or even reverse the complex maladaptive changes and pain behaviors that arise in the nervous system after injury or disease. Because the characterization of new related molecules with improved specificity and enhanced pharmacological profiles may represent a crucial step to develop more efficient steroid-based therapies, we have also discussed the potential of novel synthetic analogs of allopregnanolone as valuable molecules for the treatment of neuropathic pain.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHRONIC PAIN
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ALLOPREGNANOLONE
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PROGESTERONE
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ALLODYNIA
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MITOCHONDRIA
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-27T15:22:43Z
dc.journal.volume
39
dc.journal.number
4
dc.journal.pagination
523-537
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
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Fil: Meyer, Laurence. Université de Strasbourg; Francia
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Fil: Raggio, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
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Fil: Taleb, Omar. Université de Strasbourg; Francia
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Fil: Coronel, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Patte Mensah, Christine. Université de Strasbourg; Francia
dc.description.fil
Fil: Mensah-Nyagan, Ayikoe Guy. Université de Strasbourg; Francia
dc.journal.title
Cellular And Molecular Neurobiology.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10571-018-0618-
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/10.1007%2Fs10571-018-0618-1
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