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dc.contributor.author
Abruzzese, Giselle Adriana
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dc.contributor.author
Crisosto, Nicolás
dc.contributor.author
De Grava Kempinas, Wilma
dc.contributor.author
Sotomayor Zárate, Ramón
dc.date.available
2019-10-24T18:20:22Z
dc.date.issued
2018-10
dc.identifier.citation
Abruzzese, Giselle Adriana; Crisosto, Nicolás; De Grava Kempinas, Wilma; Sotomayor Zárate, Ramón; Developmental programming of the female neuroendocrine system by steroids; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 30; 10; 10-2018; 1-31
dc.identifier.issn
0953-8194
dc.identifier.uri
http://hdl.handle.net/11336/87234
dc.description.abstract
Developmental programming refers to processes that occur during early life that may have long-term consequences, modulating adult health and disease. Complex diseases, such as diabetes, cancer and cardiovascular disease, have a high prevalence in different populations, are multifactorial, and may have a strong environmental component. The environment interacts with organisms, affecting their behaviour, morphology and physiology. This interaction may induce permanent or long-term changes, and organisms may be more susceptible to environmental factors during certain developmental stages, such as the prenatal and early postnatal periods. Several factors have been identified as responsible for inducing the reprogramming of various reproductive and nonreproductive tissues. Among them, both natural and synthetic steroids, such as endocrine disruptors, are known to have either detrimental or positive effects on organisms depending on the dose of exposure, stage of development and biological sexual background. The present review focuses on the action of steroids and endocrine disruptors as agents involved in developmental programming and on their modulation and effects on female neuroendocrine functions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DEVELOPMENTAL PROGRAMMING
dc.subject
ENDOCRINE DISRUPTORS
dc.subject
GLUCOCORTICOIDS
dc.subject
GONADAL STEROIDS
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Developmental programming of the female neuroendocrine system by steroids
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-22T15:04:33Z
dc.journal.volume
30
dc.journal.number
10
dc.journal.pagination
1-31
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Abruzzese, Giselle Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Crisosto, Nicolás. Facultad de Medicina de la Universidad de Chile; Chile. Clinica Las Condes; Chile
dc.description.fil
Fil: De Grava Kempinas, Wilma. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Sotomayor Zárate, Ramón. Universidad de Valparaiso; Chile
dc.journal.title
Journal of Neuroendocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1111/jne.12632
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jne.12632
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