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dc.contributor.author
Burgueño, Analía
dc.contributor.author
Frabasile, Sandra
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Diaz, Luis Adrian
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Cabrera, Andrés
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Pisano, María Belén
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Rivarola, María Elisa
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Contigiani de Minio, Marta Silvia
dc.contributor.author
Delfraro, Adriana
dc.date.available
2019-10-23T13:01:33Z
dc.date.issued
2018-04
dc.identifier.citation
Burgueño, Analía; Frabasile, Sandra; Diaz, Luis Adrian; Cabrera, Andrés; Pisano, María Belén; et al.; Genomic characterization and seroprevalence studies on alphaviruses in Uruguay; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 98; 6; 4-2018; 1811-1818
dc.identifier.issn
0002-9637
dc.identifier.uri
http://hdl.handle.net/11336/87049
dc.description.abstract
Alphaviruses (Togaviridae) are arboviruses frequently associated with emerging infectious diseases. In this study, we aimed to investigate the presence of alphaviruses in Uruguay by detecting the viral genome in mosquitoes and neutralizing antibodies in equines. A total of 3,575 mosquitoes were analyzed for alphavirus genome detection. Serologic studies were performed on 425 horse sera by plaque reduction neutralization test (PRNT80) against Venezuelan equine encephalitis virus (VEEV) subtype IAB, Pixuna virus (PIXV), Rio Negro virus (RNV), western equine encephalitis virus (WEEV), and Madariaga virus (MADV). Mosquitoes belonging to six genera were captured and 82.9% were identified as Culex pipiens. Two Cx. pipiens pools collected in Fray Bentos and Las Toscas localities were alphavirus positive, and phylogenetic analyses showed that the sequences grouped into two different clusters: the lineage I of eastern equine encephalitis virus and RNV (VEEV complex), respectively. Plaque reduction neutralization test assays showed antibodies against strains of the VEEV complex, MADV, and WEEV. Rio Negro virus was the most geographically widespread virus, showing higher seroprevalences (up to 20%). Seroprevalences against VEEV IAB ranged between 4.6% and 13%; antibodies against PIXV, WEEV, and MADV were less frequent (3–4%). In conclusion, RNV exhibited the highest seroprevalence in horses, a wide geographical distribution, and viral genome was detected in Cx. pipiens mosquitoes. Madariaga virus had a low seroprevalence in equines, but an epizootic lineage typical of North America was detected in Cx. pipiens mosquitoes. Taken together, our results show that alphaviruses are present in Uruguay with variable occurrence and geographical distribution being a potential threat for human and equine health.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Tropical Medicine and Hygiene
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALPHAVIRUSES
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GENOME AMPLIFICATION
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SEROLOGICAL SURVEY
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MOSQUITOES
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Virología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Genomic characterization and seroprevalence studies on alphaviruses in Uruguay
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-08-09T15:05:33Z
dc.journal.volume
98
dc.journal.number
6
dc.journal.pagination
1811-1818
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Stanford
dc.description.fil
Fil: Burgueño, Analía. Universidad de la República. Facultad de Ciencias; Uruguay
dc.description.fil
Fil: Frabasile, Sandra. Universidad de la República. Facultad de Ciencias; Uruguay
dc.description.fil
Fil: Diaz, Luis Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología "Dr. J. M. Vanella"; Argentina
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Fil: Cabrera, Andrés. Universidad de la República. Facultad de Ciencias; Uruguay
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Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología "Dr. J. M. Vanella"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología "Dr. J. M. Vanella"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
dc.description.fil
Fil: Delfraro, Adriana. Universidad de la República. Facultad de Ciencias; Uruguay
dc.journal.title
American Journal of Tropical Medicine and Hygiene
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0980
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4269/ajtmh.17-0980
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