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dc.contributor.author
Travlou, Nikolina A.
dc.contributor.author
Algarra, Manuel
dc.contributor.author
Alcoholado, Cristina
dc.contributor.author
Cifuentes Rueda, Manuel
dc.contributor.author
Labella, Alejandro M.
dc.contributor.author
Lazaro Martinez, Juan Manuel
dc.contributor.author
Rodríguez Castellón, Enrique
dc.contributor.author
Bandosz, Teresa J.
dc.date.available
2019-10-22T20:52:28Z
dc.date.issued
2018-08
dc.identifier.citation
Travlou, Nikolina A.; Algarra, Manuel; Alcoholado, Cristina; Cifuentes Rueda, Manuel; Labella, Alejandro M.; et al.; Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites; American Chemical Society; ACS Applied Bio Materials; 1; 3; 8-2018; 693-707
dc.identifier.issn
2576-6422
dc.identifier.uri
http://hdl.handle.net/11336/87020
dc.description.abstract
Nanocomposites and hybrid materials of Ag-1,3,5- benzenetricarboxylic acid metal-organic frameworks (MOFs) with Sand N-carbon quantum dots (CQDs) were synthesized and evaluated for their antibacterial activity against representative Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacterial strains using the qualitative disk-diffusion approach and the quantitative minimum inhibitory concentration test. The composites and hybrids were found to be nontoxic to living cells. The composite formation fostered a synergistic effect that enhanced their antibacterial activity compared with those of their pristine components. Charge transfer from AgMOF to CQDs facilitated the electrostatic interactions of the composites and hybrids with the bacterial cell membranes. Enhanced bactericidal activity was linked to morphological features (a nanorod-like morphology) and specific surface chemistry. The latter affected the release of silver. Silver on the surface of the MOFs rather than silver in the bulk was found to be important. The destruction of the MOF component in the extracellular environment led to the release of silver ions, which have a high affinity to S compounds of the cell physiology. The formation of metallic silver (Ago) and silver sulfides (Ag2S) was suggested as essential for the ability of the composites and hybrids to inhibit bacterial growth. To the best of our knowledge, this is the first study that introduces the bactericidal effect of AgMOF-CQDs composites and hybrids.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIBACTERIAL ACTIVITY
dc.subject
CARBON QUANTUM DOTS
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COMPOSITES
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METAL-ORGANIC FRAMEWORK
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SILVER
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SYNERGY
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
dc.subject.classification
Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Carbon quantum dot surface-chemistry-dependent ag release governs the high antibacterial activity of Ag-metal-organic framework composites
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-16T20:57:30Z
dc.journal.volume
1
dc.journal.number
3
dc.journal.pagination
693-707
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Travlou, Nikolina A.. City University of New York; Estados Unidos
dc.description.fil
Fil: Algarra, Manuel. Universidad de Málaga; España
dc.description.fil
Fil: Alcoholado, Cristina. Universidad de Málaga; España. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; España
dc.description.fil
Fil: Cifuentes Rueda, Manuel. Universidad de Málaga; España. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; España
dc.description.fil
Fil: Labella, Alejandro M.. Universidad de Málaga; España
dc.description.fil
Fil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Rodríguez Castellón, Enrique. Universidad de Málaga; España
dc.description.fil
Fil: Bandosz, Teresa J.. City University of New York; Estados Unidos
dc.journal.title
ACS Applied Bio Materials
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsabm.8b00166
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acsabm.8b00166
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