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dc.contributor.author
Wolf, Ivan Rodrigo
dc.contributor.author
Paschoal, Alexandre Rossi
dc.contributor.author
Quiroga, Cecilia
dc.contributor.author
Domingues, Douglas Silva
dc.contributor.author
de Souza, Rogério Fernandes
dc.contributor.author
Pretto Giordano, Lucienne Garcia
dc.contributor.author
Vilas Boas, Laurival Antonio
dc.date.available
2019-10-22T19:00:16Z
dc.date.issued
2018-07
dc.identifier.citation
Wolf, Ivan Rodrigo; Paschoal, Alexandre Rossi; Quiroga, Cecilia; Domingues, Douglas Silva; de Souza, Rogério Fernandes; et al.; Functional annotation and distribution overview of RNA families in 27 Streptococcus agalactiae genomes; BioMed Central; BMC Genomics; 19; 556; 7-2018; 1-11
dc.identifier.issn
1471-2164
dc.identifier.uri
http://hdl.handle.net/11336/86968
dc.description.abstract
Background: Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is a Gram-positive bacterium that colonizes the gastrointestinal and genitourinary tract of humans. This bacterium has also been isolated from various animals, such as fish and cattle. Non-coding RNAs (ncRNAs) can act as regulators of gene expression in bacteria, such as Streptococcus pneumoniae and Streptococcus pyogenes. However, little is known about the genomic distribution of ncRNAs and RNA families in S. agalactiae. Results: Comparative genome analysis of 27 S. agalactiae strains showed more than 5 thousand genomic regions identified and classified as Core, Exclusive, and Shared genome sequences. We identified 27 to 89 RNA families per genome distributed over these regions, from these, 25 were in Core regions while Shared and Exclusive regions showed variations amongst strains. We propose that the amount and type of ncRNA present in each genome can provide a pattern to contribute in the identification of the clonal types. Conclusions: The identification of RNA families provides an insight over ncRNAs, sRNAs and ribozymes function, that can be further explored as targets for antibiotic development or studied in gene regulation of cellular processes. RNA families could be considered as markers to determine infection capabilities of different strains. Lastly, pan-genome analysis of GBS including the full range of functional transcripts provides a broader approach in the understanding of this pathogen.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
STREPTOCOCCUS
dc.subject
NON-CODING RNAS
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PAN-GENOME
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RNA FAMILIES
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TRANSCRIPTOME
dc.subject.classification
Biología Celular, Microbiología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Functional annotation and distribution overview of RNA families in 27 Streptococcus agalactiae genomes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-10T15:00:19Z
dc.identifier.eissn
1471-2164
dc.journal.volume
19
dc.journal.number
556
dc.journal.pagination
1-11
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Wolf, Ivan Rodrigo. Universidade Estadual de Londrina; Brasil
dc.description.fil
Fil: Paschoal, Alexandre Rossi. Universidade Federal do Paraná; Brasil
dc.description.fil
Fil: Quiroga, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Domingues, Douglas Silva. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: de Souza, Rogério Fernandes. Universidade Estadual de Londrina; Brasil
dc.description.fil
Fil: Pretto Giordano, Lucienne Garcia. Universidade Estadual de Londrina; Brasil
dc.description.fil
Fil: Vilas Boas, Laurival Antonio. Universidade Estadual de Londrina; Brasil
dc.journal.title
BMC Genomics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4951-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1186/s12864-018-4951-z


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