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dc.contributor.author
Wong, Vincent Wai-Sun
dc.contributor.author
Adams, Leon A.
dc.contributor.author
de Lédinghen, Victor
dc.contributor.author
Wong, Grace Lai-Hung
dc.contributor.author
Sookoian, Silvia Cristina
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dc.date.available
2019-10-21T20:50:09Z
dc.date.issued
2018-08
dc.identifier.citation
Wong, Vincent Wai-Sun; Adams, Leon A.; de Lédinghen, Victor; Wong, Grace Lai-Hung; Sookoian, Silvia Cristina; Noninvasive biomarkers in NAFLD and NASH — current progress and future promise; Nature Publishing Group; Nature Reviews Gastroenterology & Hepatology; 15; 8; 8-2018; 461-478
dc.identifier.issn
1759-5045
dc.identifier.uri
http://hdl.handle.net/11336/86757
dc.description.abstract
Nonalcoholic fatty liver disease (NAFLD) affects 25% of the global adult population and is the most common chronic liver disease worldwide. Nonalcoholic steatohepatitis (NASH) is the active form of NAFLD, with hepatic necroinflammation and faster fibrosis progression. With an increasing number of patients developing NASH-related end-stage liver disease and pharmacological treatments on the horizon, there is a pressing need to develop NAFLD and NASH biomarkers for prognostication, selection of patients for treatment and monitoring. This requirement is particularly true as liver biopsy utility is limited by its invasive nature, poor patient acceptability and sampling variability. This article reviews current and potential biomarkers for different features of NAFLD, namely, steatosis, necroinflammation and fibrosis. For each biomarker, we evaluate its accuracy, reproducibility, responsiveness, feasibility and limitations. We cover biochemical, imaging and genetic biomarkers and discuss biomarker discovery in the omics era.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NASH
dc.subject
NAFLD
dc.subject
BIOMARKERS
dc.subject
OMICS
dc.subject.classification
Gastroenterología y Hepatología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Noninvasive biomarkers in NAFLD and NASH — current progress and future promise
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-30T19:16:08Z
dc.journal.volume
15
dc.journal.number
8
dc.journal.pagination
461-478
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Wong, Vincent Wai-Sun. Chinese University Of Hong Kong; Hong Kong
dc.description.fil
Fil: Adams, Leon A.. University of Western Australia; Australia
dc.description.fil
Fil: de Lédinghen, Victor. Universite de Bordeaux; Francia
dc.description.fil
Fil: Wong, Grace Lai-Hung. Chinese University Of Hong Kong; Hong Kong
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Nature Reviews Gastroenterology & Hepatology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41575-018-0014-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41575-018-0014-9
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