Mostrar el registro sencillo del ítem
dc.contributor.author
Vega Benedetti, Ana Florencia
dc.contributor.author
Saucedo, Cinthia Natalia
dc.contributor.author
Zavattari, Patrizia
dc.contributor.author
Vanni, Roberta
dc.contributor.author
Royo, Felix
dc.contributor.author
LLavero, Freancisco
dc.contributor.author
Zugaza, José L.
dc.contributor.author
Parada, Luis Antonio
dc.date.available
2019-10-21T17:54:42Z
dc.date.issued
2018-08-28
dc.identifier.citation
Vega Benedetti, Ana Florencia; Saucedo, Cinthia Natalia; Zavattari, Patrizia; Vanni, Roberta; Royo, Felix; et al.; PLAGL1 gene function during hepatoma cells proliferation; Impact Journals LLC; Oncotarget; 9; 67; 28-8-2018; 32775-32794
dc.identifier.uri
http://hdl.handle.net/11336/86657
dc.description.abstract
Hepatocellular carcinoma develops as a multistep process, in which cell cycle deregulation is a central feature, resulting in unscheduled proliferation. The PLAGL1 gene encodes a homonym zinc finger protein that is involved in cell-proliferation control. We determined the genomic profile and the transcription and expression level of PLAGL1, simultaneously with that of its molecular partners p53, PPARγ and p21, in cell-lines derived from patients with liver cancer, during in vitro cell growth. Our investigations revealed that genomic and epigenetic changes of PLAGL1 are also present in hepatoma cell-lines. Transcription of PLAGL1 in tumor cells is significantly lower than in normal fibroblasts, but no significant differences in terms of protein expression were detected between these two cell-types, indicating that there is not a direct relationship between the gene transcriptional activity and protein expression. RT-PCR analyses on normal fibroblasts, used as control, also showed that PLAGL1 and p53 genes transcription occurs as an apparent orchestrated process during normal cells proliferation, which gets disturbed in cancer cells. Furthermore, abnormal trafficking of the PLAGL1 protein may occur in hepatocarcinogenesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Impact Journals LLC
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CELL PROLIFERATION
dc.subject
CHROMOSOME
dc.subject
HEPATOCELLULAR CARCINOMA
dc.subject
METHYLATION
dc.subject
PLAGL1
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
PLAGL1 gene function during hepatoma cells proliferation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-16T14:27:55Z
dc.identifier.eissn
1949-2553
dc.journal.volume
9
dc.journal.number
67
dc.journal.pagination
32775-32794
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Vega Benedetti, Ana Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
dc.description.fil
Fil: Saucedo, Cinthia Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
dc.description.fil
Fil: Zavattari, Patrizia. University of Cagliari; Italia
dc.description.fil
Fil: Vanni, Roberta. University of Cagliari; Italia
dc.description.fil
Fil: Royo, Felix. CIC BioGUNE CIBERehd; España
dc.description.fil
Fil: LLavero, Freancisco. Universidad del País Vasco; España. IKERBASQUE; España
dc.description.fil
Fil: Zugaza, José L.. Universidad del País Vasco; España. IKERBASQUE; España
dc.description.fil
Fil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
dc.journal.title
Oncotarget
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.18632/oncotarget.25996
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25996&path[]=81113
Archivos asociados