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dc.contributor.author
Bazin, Jérémie  
dc.contributor.author
Romero, Natali  
dc.contributor.author
Rigo, Richard  
dc.contributor.author
Charon, Celine  
dc.contributor.author
Blein, Thomas  
dc.contributor.author
Ariel, Federico Damian  
dc.contributor.author
Crespi, Martin  
dc.date.available
2019-10-21T17:27:44Z  
dc.date.issued
2018-08  
dc.identifier.citation
Bazin, Jérémie; Romero, Natali; Rigo, Richard; Charon, Celine; Blein, Thomas; et al.; Nuclear speckle rna binding proteins remodel alternative splicing and the non-coding arabidopsis transcriptome to regulate a cross-talk between auxin and immune responses; Frontiers Media S.A.; Frontiers in Plant Science; 9; 8-2018  
dc.identifier.issn
1664-462X  
dc.identifier.uri
http://hdl.handle.net/11336/86627  
dc.description.abstract
Nuclear speckle RNA binding proteins (NSRs) act as regulators of alternative splicing (AS) and auxin-regulated developmental processes such as lateral root formation in Arabidopsis thaliana. These proteins were shown to interact with specific alternatively spliced mRNA targets and at least with one structured lncRNA, named Alternative Splicing Competitor RNA. Here, we used genome-wide analysis of RNAseq to monitor the NSR global role on multiple tiers of gene expression, including RNA processing and AS. NSRs affect AS of 100s of genes as well as the abundance of lncRNAs particularly in response to auxin. Among them, the FPA floral regulator displayed alternative polyadenylation and differential expression of antisense COOLAIR lncRNAs in nsra/b mutants. This may explains the early flowering phenotype observed in nsra and nsra/b mutants. GO enrichment analysis of affected lines revealed a novel link of NSRs with the immune response pathway. A RIP-seq approach on an NSRa fusion protein in mutant background identified that lncRNAs are privileged direct targets of NSRs in addition to specific AS mRNAs. The interplay of lncRNAs and AS mRNAs in NSR-containing complexes may control the crosstalk between auxin and the immune response pathway.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers Media S.A.  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ALTERNATIVE SPLICING  
dc.subject
AUXIN  
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IMMUNE RESPONSE  
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RNA BINDING PROTEINS  
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RNP COMPLEXES  
dc.subject.classification
Bioquímica y Biología Molecular  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Nuclear speckle rna binding proteins remodel alternative splicing and the non-coding arabidopsis transcriptome to regulate a cross-talk between auxin and immune responses  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-18T18:44:03Z  
dc.journal.volume
9  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Bazin, Jérémie. Universite Paris-sud Xi;  
dc.description.fil
Fil: Romero, Natali. Universite Paris-sud Xi;  
dc.description.fil
Fil: Rigo, Richard. Universite Paris-sud Xi;  
dc.description.fil
Fil: Charon, Celine. Universite Paris-sud Xi;  
dc.description.fil
Fil: Blein, Thomas. Universite Paris-sud Xi;  
dc.description.fil
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina  
dc.description.fil
Fil: Crespi, Martin. Universite Paris-sud Xi;  
dc.journal.title
Frontiers in Plant Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fpls.2018.01209