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Artículo

Altered Expression of Anti-Müllerian Hormone during the Early Stage of Bovine Persistent Ovarian Follicles

Díaz, Pablo UrielIcon ; Rey, FlorenciaIcon ; Gareis, Natalia CarolinaIcon ; Notaro, Ulises SebastiánIcon ; Matiller, ValentinaIcon ; Belotti, Eduardo MatíasIcon ; Stassi, Antonela FlorenciaIcon ; Salvetti, Natalia RaquelIcon ; Ortega, Hugo HectorIcon
Fecha de publicación: 01/2018
Editorial: Elsevier
Revista: Journal Of Comparative Pathology
ISSN: 1532-3129
e-ISSN: 0021-9975
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Ciencias Veterinarias

Resumen

Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein expressed exclusively in the gonads. This hormone is an important regulator of the early growth of follicles through inhibitory effects on the recruitment of primordial follicles into the pool of growing follicles and on granulosa cell proliferation. Cystic ovarian disease (COD) is an important disorder affecting the fertility of dairy cattle. In the present study, we evaluated the expression of AMH in granulosa cells and AMH secretion into follicular fluid in pre-ovulatory follicles from control cows, animals with spontaneously arising COD and during the development of the disease, at 5, 10 and 15 days of follicular persistence. To this end, after an oestrous synchronization protocol, low doses of progesterone was administered for 5, 10 and 15 days after the expected day of ovulation (day 0 of follicular persistence) in treated cows (groups P5, P10 and P15, respectively), using an intravaginal progesterone-releasing device. Results showed a decrease in the expression of AMH in granulosa cells throughout folliculogenesis (P <0.05) and in the spontaneously arising follicular cysts and persistent follicles related to the control group (P <0.05). There was also a higher concentration of AMH in the follicular fluid of persistent follicles at 10 and 15 days of follicular persistence (P <0.05). Together, these results may indicate an alteration in AMH expression and secretion, which occurs early in folliculogenesis and incipiently during the development of COD, and which could contribute to the recurrence of this disease in cattle.
Palabras clave: ANTI-MÜLLERIAN HORMONE , COW , CYSTIC OVARIAN DISEASE , FOLLICULAR PERSISTENCE
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/86499
DOI: http://dx.doi.org/10.1016/j.jcpa.2017.10.175
URL: https://www.sciencedirect.com/science/article/abs/pii/S0021997517303122
Colecciones
Articulos(ICIVET-LITORAL)
Articulos de INST. DE CIENCIAS VETERINARIAS DEL LITORAL
Citación
Díaz, Pablo Uriel; Rey, Florencia; Gareis, Natalia Carolina; Notaro, Ulises Sebastián; Matiller, Valentina; et al.; Altered Expression of Anti-Müllerian Hormone during the Early Stage of Bovine Persistent Ovarian Follicles; Elsevier; Journal Of Comparative Pathology; 158; 1-2018; 22-31
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