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Artículo

Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends

Tamma, Grazia; Valenti, Giovanna; Grossini, Elena; Donnini, Sandra; Marino, Angela; Marinelli, Raul AlbertoIcon ; Calamita, Giuseppe
Fecha de publicación: 03/2018
Editorial: Hindawi Publishing Corporation
Revista: Oxidative Medicine and Cellular Longevity
ISSN: 1942-0900
e-ISSN: 1942-0994
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.
Palabras clave: AQUAPORIN , OXIDATIVE STRESS , SIGNALING , AGING
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/86347
URL: https://www.hindawi.com/journals/omcl/2018/1501847/
DOI: http://dx.doi.org/10.1155/2018/1501847
Colecciones
Articulos(IFISE)
Articulos de INST.DE FISIOLOGIA EXPERIMENTAL (I)
Citación
Tamma, Grazia; Valenti, Giovanna; Grossini, Elena; Donnini, Sandra; Marino, Angela; et al.; Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2018; 3-2018; 1-14; 1501847
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