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dc.contributor.author
Fishkel, Vanina S.
dc.contributor.author
Monge, Fernando C.
dc.contributor.author
von Petery, Felicitas M.
dc.contributor.author
Tapper, Karen E.
dc.contributor.author
Peña, Teresa M.
dc.contributor.author
Torres, Florencia
dc.contributor.author
Poletta, Fernando Adrián
dc.contributor.author
Elgart, Jorge Federico
dc.contributor.author
Avagnina, Alejandra
dc.contributor.author
Denninghoff, Valeria Cecilia
dc.date.available
2019-10-18T15:17:58Z
dc.date.issued
2019-05
dc.identifier.citation
Fishkel, Vanina S.; Monge, Fernando C.; von Petery, Felicitas M.; Tapper, Karen E.; Peña, Teresa M.; et al.; Clinical and Economic Value of p16INK4a for the Differential Diagnosis of Morphologic Cervical Intraepithelial Neoplasia 2; Lippincott Williams; Appl Immunohistochem Mol Morphol; 27; 9 ; 5-2019; 672-677
dc.identifier.issn
1541-2016
dc.identifier.uri
http://hdl.handle.net/11336/86343
dc.description.abstract
The detection of high-grade intraepithelial lesions requires highly sensitive and specific methods that allow more accurate diagnoses. This contributes to a proper management of preneoplastic lesions, thus avoiding overtreatment. The purpose of this study was to analyze the value of immunostaining for p16 in the morphologic assessment of cervical intraepithelial neoplasia 2 lesions, to help differentiate between low-grade (p16-negative) and high-grade (p16-positive) squamous intraepithelial lesions. The direct medical cost of the treatment of cervical intraepithelial neoplasia 2 morphologic lesions was estimated. A retrospective observational cross-sectional study was carried out. This study analyzed 46 patients treated with excisional procedures because of cervical intraepithelial neoplasia 2 lesions, using loop electrosurgical excision procedures. Immunostaining for the biomarker was performed. For the estimation of overtreatment, percentages (%) and their 95% confidence interval were calculated. Of the 41 patients analyzed, 32 (78%) showed overexpression of p16 and 9 (22%) were negative (95% confidence interval, 11%-38%). Mean follow-up was 2.9 years, using cervical cytology testing (Pap) and colposcopy. High-risk human papillomavirus DNA tests were performed in 83% of patients. These retrospective results reveal the need for larger biopsy samples, which would allow a more accurate prediction of lesion risk. Considering the cost of p16 staining, and assuming the proper management of the low-grade lesion, an average of US$919 could be saved for each patient with a p16-negative result, which represents a global direct cost reduction of 10%
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MOROHOLOGIC CERVICAL INTRAEPITHELIAL NEOPLASIA 2
dc.subject
BIOMARKER
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p16INK4a
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IMMUNOSTAINING
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MOROHOLOGIC CERVICAL INTRAEPITHELIAL NEOPLASIA 2
dc.subject.classification
Obstetricia y Ginecología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Clinical and Economic Value of p16INK4a for the Differential Diagnosis of Morphologic Cervical Intraepithelial Neoplasia 2
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-09T20:43:47Z
dc.journal.volume
27
dc.journal.number
9
dc.journal.pagination
672-677
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Fishkel, Vanina S.. Centro de Educación Medica E Invest.clinicas; Argentina
dc.description.fil
Fil: Monge, Fernando C.. Centro de Educación Medica E Invest.clinicas; Argentina
dc.description.fil
Fil: von Petery, Felicitas M.. Centro de Educación Medica E Invest.clinicas; Argentina
dc.description.fil
Fil: Tapper, Karen E.. Centro de Educación Medica E Invest.clinicas; Argentina
dc.description.fil
Fil: Peña, Teresa M.. Centro de Educación Medica E Invest.clinicas; Argentina
dc.description.fil
Fil: Torres, Florencia. Centro de Educación Medica E Invest.clinicas; Argentina
dc.description.fil
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
dc.description.fil
Fil: Elgart, Jorge Federico. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Avagnina, Alejandra. Centro de Educación Medica E Invest.clinicas; Argentina
dc.description.fil
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
dc.journal.title
Appl Immunohistochem Mol Morphol
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/PAI.0000000000000674
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/29734247
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