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dc.contributor.author
Urteaga, Raul  
dc.contributor.author
Elizalde, Emanuel  
dc.contributor.author
Berli, Claudio Luis Alberto  
dc.date.available
2019-10-16T20:26:22Z  
dc.date.issued
2018-05  
dc.identifier.citation
Urteaga, Raul; Elizalde, Emanuel; Berli, Claudio Luis Alberto; Transverse solute dispersion in microfluidic paper-based analytical devices (μPADs); Royal Society of Chemistry; Analyst; 143; 10; 5-2018; 2259-2266  
dc.identifier.issn
0003-2654  
dc.identifier.uri
http://hdl.handle.net/11336/86085  
dc.description.abstract
The transport of molecules and particles across adjacent flow streams is a key process in several operations implemented in microfluidic paper-based analytical devices (μPADs). Here, the transverse dispersion of analytes was quantitatively evaluated by theory and experiments. Different tests were carried out to independently measure the coefficients of both Brownian diffusion and mechanical dispersion under capillary-driven flow. The dispersion width was found to be independent of fluid velocity and analyte properties, and fully determined by the dispersivity coefficient, which is a characteristic of the paper microstructure. This information introduces a change of paradigm for the design of mixers, diluters, and concentration gradient generators on μPADs; therefore, efforts were made to rationalize these operations on paper. The research reveals that mixers and concentration gradient generators can be much more efficient than their counterparts made on conventional microchannels; in contrast, separators such as the H-filter need to be appropriately engineered on paper, because the working principle can be hindered by mechanical dispersion. The knowledge gained throughout this work would contribute to the design of μPADs with a new level of precision and control over the formation of localized concentration profiles.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Royal Society of Chemistry  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
MICROFLUIDICA BASADA EN PAPEL  
dc.subject.classification
Física de los Fluidos y Plasma  
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Ciencias Físicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Transverse solute dispersion in microfluidic paper-based analytical devices (μPADs)  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-10T14:59:06Z  
dc.journal.volume
143  
dc.journal.number
10  
dc.journal.pagination
2259-2266  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Cambridge  
dc.description.fil
Fil: Urteaga, Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Física del Litoral. Universidad Nacional del Litoral. Instituto de Física del Litoral; Argentina  
dc.description.fil
Fil: Elizalde, Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Física del Litoral. Universidad Nacional del Litoral. Instituto de Física del Litoral; Argentina  
dc.description.fil
Fil: Berli, Claudio Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina  
dc.journal.title
Analyst  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an00149a  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/C8AN00149A