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dc.contributor.author
Waxman Dova, Samanta
dc.contributor.author
Prados, Ana Paula
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De Lucas, Julio
dc.contributor.author
Andres, Manuel Ignacio San
dc.contributor.author
Sassaroli, Juan Carlos
dc.contributor.author
Orozco, Maria Marcela
dc.contributor.author
Argibay, Hernán Darío
dc.contributor.author
Rodriguez, Casilda
dc.date.available
2019-10-16T19:55:55Z
dc.date.issued
2013-09
dc.identifier.citation
Waxman Dova, Samanta; Prados, Ana Paula; De Lucas, Julio; Andres, Manuel Ignacio San; Sassaroli, Juan Carlos; et al.; Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus); Assoc Avian Veterinarians; Journal Of Avian Medicine And Surgery; 27; 3; 9-2013; 180-186
dc.identifier.issn
1082-6742
dc.identifier.uri
http://hdl.handle.net/11336/86056
dc.description.abstract
To determine the dosage of enrofloxacin in southern crested caracaras (Caracara plancus), plasma concentrations of enrofloxacin were measured by high-performance liquid chromatography after intravenous (IV) (5 mg/kg) and intramuscular (IM) (10 mg/kg) administration. This compound presented a relatively high volume of distribution (2.09 L/kg), a total body clearance of 0.24 L/kg·h, and a long permanence as shown by an elimination half-life of 7.81 hours after IV administration and a terminal half-life of 6.58 hours after IM administration. The areas under the concentration-time curves (AUC) were 21.92 and 34.38 μg·h/mL for IM and IV administration, respectively. Enrofloxacin was rapidly absorbed after IM administration with a time to reach maximum concentration of 0.72 hours and bioavailability of 78.76%. After IM administration, the peak drug concentration (Cmax) was 3.92 μg/mL. Values of minimum inhibitory concentration (MIC), Cmax, and AUC have been used to predict the clinical efficacy of a drug in treating bacterial infections, with a Cmax/MIC value of 10 and an AUC/MIC ratio of 125-250 associated with optimal bactericidal effects. By using the study data and a MIC breakpoint of 0.25 μg/mL, values of Cmax/MIC were 13.74 and 15.94 and for AUC/MIC were 90.73 and 139.63, for the IV and IM routes respectively. For the treatment of infectious diseases caused by microorganisms with MIC ≤0.25 μg/mL, the calculated optimal dosages were 7.5 and 9.5 mg/kg q24h by the IV and IM routes, respectively. For less susceptible bacteria, a dose increase should be evaluated. To treat caracara by the IV route against microorganisms with MIC ≤0.25 μg/mL, the dose should be higher than the 5 mg/kg used in our study, but possible side effects derived from an increase in the IV dose and efficacy in sick birds should be assessed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Assoc Avian Veterinarians
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CARACARA PLANCUS
dc.subject
ENROFLOXACIN
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FLUOROQUINOLONES PHARMACOKINETICS
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PHARMACODYNAMICS
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SOUTHERN CREASTED CARACARS
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-02T20:55:10Z
dc.journal.volume
27
dc.journal.number
3
dc.journal.pagination
180-186
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Waxman Dova, Samanta. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Prados, Ana Paula. Universidad de Buenos Aires; Argentina
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Fil: De Lucas, Julio. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Andres, Manuel Ignacio San. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Sassaroli, Juan Carlos. No especifica;
dc.description.fil
Fil: Orozco, Maria Marcela. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Argibay, Hernán Darío. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rodriguez, Casilda. Universidad Complutense de Madrid; España
dc.journal.title
Journal Of Avian Medicine And Surgery
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.bioone.org/doi/full/10.1647/2012-022
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1647/2012-022
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