Artículo
Valorization of Oleuropein via Tunable Acid-Promoted Methanolysis
Cavaca, Lídia A. S.; Rodrigues, Catarina A. B.; Simeonov, Svilen P.; Gomes, Rafael F. A.; Coelho, Jaime A. S.; Romanelli, Gustavo Pablo
; Sathicq, Angel Gabriel
; Martínez, José J.; Afonso, Carlos A. M.
Fecha de publicación:
07/2018
Editorial:
Wiley VCH Verlag
Revista:
Chemsuschem
ISSN:
1864-5631
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The acid-promoted methanolysis of oleuropein was studied using a variety of homogeneous and heterogeneous acid catalysts. Exclusive cleavage of the acetal bond between the glucoside and the monoterpene subunits or further hydrolysis of the hydroxytyrosol ester and subsequent intramolecular rearrangement were observed upon identification of the most efficient catalyst and experimental conditions. Furthermore, selected conditions were tested using oleuropein under continuous flow and using a crude mixture extracted from olive leaves under batch. Formation of (−)-methyl elenolate was also observed in this study, which is a reported precursor for the synthesis of the antihypertensive drug (−)-ajmalicine.
Palabras clave:
BIOMASS
,
HETEROGENEOUS CATALYSIS
,
HOMOGENEOUS CATALYSIS
,
OLEUROPEIN
,
SOLVOLYSIS
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Identificadores
Colecciones
Articulos(CINDECA)
Articulos de CENTRO DE INV EN CS.APLICADAS "DR.JORGE J.RONCO"
Articulos de CENTRO DE INV EN CS.APLICADAS "DR.JORGE J.RONCO"
Citación
Cavaca, Lídia A. S.; Rodrigues, Catarina A. B.; Simeonov, Svilen P.; Gomes, Rafael F. A.; Coelho, Jaime A. S.; et al.; Valorization of Oleuropein via Tunable Acid-Promoted Methanolysis; Wiley VCH Verlag; Chemsuschem; 11; 14; 7-2018; 2300-2305
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