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dc.contributor.author
March, Samanta Mabel
dc.contributor.author
Abate, Paula
dc.contributor.author
Spear, Norman E.
dc.contributor.author
Molina, Juan Carlos
dc.date.available
2019-10-15T20:21:40Z
dc.date.issued
2013-04
dc.identifier.citation
March, Samanta Mabel; Abate, Paula; Spear, Norman E.; Molina, Juan Carlos; The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats; Springer; Psychopharmacology; 226; 3; 4-2013; 491-499
dc.identifier.issn
0033-3158
dc.identifier.uri
http://hdl.handle.net/11336/85967
dc.description.abstract
Rationale: Animal studies indicate that central acetaldehyde, dependent on catalase metabolism of ethanol (EtOH), modulates ethanol reinforcement. Brain catalase activity and acetaldehyde (ACD) production are significantly higher in rat pups compare d with adults. Interestingly, infant rats show high EtOH affinity for alcohol consumption and are particularly sensitive to the drug's reinforcing effects. Objectives: We tested whether central ACD is necessary and sufficient to induce appetitive conditioning in newborn rats through the artificial nipple technique. Methods: Vehicle, EtOH (100 mg%), and acetaldehyde (0.35 μmol) were administered into the cisterna magna (1 μl). Half of the animals also received a central administration of 75 μg (experiment 1) or 40 μg of d-penicillamine (experiment 2). Afterwards, pups were exposed to an olfactory cue (conditioned stimulus). One hour later, neonates were tested with an artificial nipple in the presence of the conditioned cue. Nipple attachment duration, mean grasp duration, and number of nipple disengagements served as dependent variables. Results: Positive responses to the scented nipple occurred in neonates conditioned with EtOH or ACD (experiments 1 and 2). In experiment 1, there were indications that d-penicillamine weakened the reinforcing effects of EtOH and ACD. In experiment 2, d-penicillamine (40 μg) significantly inhibited appetitive conditioned responses dependent upon EtOH or ACD. Conclusions: Appetitive conditioning was observed when employing either central EtOH or ACD as unconditioned stimuli. Central abduction of ACD inhibited conditioned appetitive responsiveness to the surrogate nipple. Central ACD is involved in the determination or modulation of EtOH's motivational properties during early stages in development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACETALDEHYDE
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D-PENICILLAMINE
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ETHANOL
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NEONATE
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ONTOGENY
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REINFORCEMENT
dc.subject
SUCKLING
dc.subject.classification
Otras Psicología
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Psicología
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CIENCIAS SOCIALES
dc.title
The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-15T18:22:08Z
dc.identifier.eissn
1432-2072
dc.journal.volume
226
dc.journal.number
3
dc.journal.pagination
491-499
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: March, Samanta Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
dc.description.fil
Fil: Abate, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
dc.description.fil
Fil: Spear, Norman E.. University of Binghamton; Estados Unidos
dc.description.fil
Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. University of Binghamton; Estados Unidos
dc.journal.title
Psychopharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00213-012-2920-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s00213-012-2920-9
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