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dc.contributor.author
Vialou, Vincent F.
dc.contributor.author
Cui, Huxing
dc.contributor.author
Perello, Mario
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Mahgoub, Melissa A.
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Yu, Hana G.
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Rush, Augustus J.
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Pranav, Heena
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Jung, Saendy
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Yangisawa, Masashi
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Zigman, Jeffrey M.
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Elmquist, Joel K.
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Nestler, Eric J.
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Lutter, Michael
dc.date.available
2019-10-15T17:59:26Z
dc.date.issued
2011-07
dc.identifier.citation
Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; et al.; A role for ΔfosB in calorie restriction-induced metabolic changes; Elsevier Science Inc; Biological Psychiatry; 70; 2; 7-2011; 204-207
dc.identifier.issn
0006-3223
dc.identifier.uri
http://hdl.handle.net/11336/85917
dc.description.abstract
Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
APPETITE
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FEEDING
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METABOLISM
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NUCLEUS ACCUMBENS
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OREXIN
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A role for ΔfosB in calorie restriction-induced metabolic changes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-24T17:37:20Z
dc.journal.volume
70
dc.journal.number
2
dc.journal.pagination
204-207
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Vialou, Vincent F.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
dc.description.fil
Fil: Cui, Huxing. University of Texas. Southwestern Medical Center; Estados Unidos
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Fil: Perello, Mario. University of Texas. Southwestern Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.description.fil
Fil: Mahgoub, Melissa A.. University of Texas. Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Yu, Hana G.. University of Texas. Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Rush, Augustus J.. University of Texas. Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Pranav, Heena. University of Texas. Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Jung, Saendy. University of Texas. Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Yangisawa, Masashi. University of Texas. Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Zigman, Jeffrey M.. University of Texas. Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Elmquist, Joel K.. University of Texas. Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Nestler, Eric J.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
dc.description.fil
Fil: Lutter, Michael. University of Texas. Southwestern Medical Center; Estados Unidos
dc.journal.title
Biological Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125466/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006322310012540
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.biopsych.2010.11.027


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