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Artículo

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

Rybak Wolf, Agnieszka; Stottmeister, Christin; Glažar, Petar; Jens, Marvin; Pino, Natalia; Giusti, Sebastian; Hanan, Mor; Behm, Mikaela; Bartok, Osnat; Ashwal Fluss, Reut; Herzog, Margareta; Schreyer, Luisa; Papavasileiou, Panagiotis; Ivanov, Andranik; Öhman, Marie; Refojo, DamianIcon ; Kadener, Sebastian; Rajewsky, Nikolaus
Fecha de publicación: 12/2014
Editorial: Cell Press
Revista: Molecular Cell
ISSN: 1097-2765
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers.
Palabras clave: circular RNAs , non-coding RNA , brain
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/85840
DOI: http://dx.doi.org/10.1016/j.molcel.2015.03.027
URL: http://dx.doi.org/ sciencedirect.com/science/article/pii/S109727651500218X
Colecciones
Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Citación
Rybak Wolf, Agnieszka; Stottmeister, Christin; Glažar, Petar; Jens, Marvin; Pino, Natalia; et al.; Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed; Cell Press; Molecular Cell; 58; 5; 12-2014; 870-885
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