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Artículo

Alveolar bone loss associated to periodontal disease in lead intoxicated rats under environmental hypoxia

Terrizzi, Antonela RominaIcon ; Fernández Solari, José JavierIcon ; Lee, Ching Ming; Bozzini, Clarisa; Mandalunis, Patricia Mónica; Elverdín, Juan Carlos; Conti, Maria Ines; Martinez, Maria del Pilar
Fecha de publicación: 07/2013
Editorial: Pergamon-Elsevier Science Ltd
Revista: Archives of Oral Biology
ISSN: 0003-9969
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Previously reported studies from this laboratory revealed that rats chronically intoxicated with lead (Pb) under hypoxic conditions (HX) impaired growth parameters and induced damages on femoral and mandibular bones predisposing to fractures. We also described periodontal inflammatory processes under such experimental conditions. Periodontitis is characterised by inflammation of supporting tissues of the teeth that result in alveolar bone loss. The existence of populations living at high altitudes and exposed to lead contamination aimed us to establish the macroscopic, biochemical and histological parameters consistent with a periodontal disease in the same rat model with or without experimental periodontitis (EP). Sixty female rats were divided into: Control; Pb (1000 ppm of lead acetate in drinking water); HX (506 mbar) and PbHX (both treatments simultaneously). EP was induced by placing ligatures around the molars of half of the rats during the 14 days previous to the autopsy. Hemi-mandibles were extracted to evaluate bone loss by histomorphometrical techniques. TNFα plasmatic concentration was greater (p < 0.01) in Pb and HX animals. TBA-RS content was significantly higher in gums of rats with or without EP only by means of Pb. The SMG PGE2 content increased by Pb or HX was higher in PbHX rats (p < 0.01). Pb and HX increased EP induced alveolar bone loss, while Pb showed spontaneous bone loss also. In conclusion, these results show that lead intoxication under hypoxic environment enhanced not only alveolar bone loss but also systemic and oral tissues inflammatory parameters, which could aggravate the physiopathological alterations produced by periodontal disease.
Palabras clave: BONE LOSS , ENVIRONMENTAL HYPOXIA , LEAD POISONING , PERIODONTITIS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/85838
DOI: http://dx.doi.org/10.1016/j.archoralbio.2013.06.010
URL: https://www.sciencedirect.com/science/article/pii/S0003996913002057
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Terrizzi, Antonela Romina; Fernández Solari, José Javier; Lee, Ching Ming; Bozzini, Clarisa; Mandalunis, Patricia Mónica; et al.; Alveolar bone loss associated to periodontal disease in lead intoxicated rats under environmental hypoxia; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 58; 10; 7-2013; 1407-1414
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