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dc.contributor.author
Cabezas, Ricardo
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Ávila, Marcos
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Gonzalez Santos, Janneth
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dc.contributor.author
El Bachá, Ramon Santos
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Báez, Eliana
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Garcia Segura, Luis Miguel
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dc.contributor.author
Coronel, Juan Camilo Jurado
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Capani, Francisco
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Cardona Gomez, Gloria Patricia
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Barreto, George E.
dc.date.available
2019-10-11T21:57:36Z
dc.date.issued
2014-08
dc.identifier.citation
Cabezas, Ricardo; Ávila, Marcos; Gonzalez Santos, Janneth; El Bachá, Ramon Santos; Báez, Eliana; et al.; Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease; Frontiers Research Foundation; Frontiers in Cellular Neuroscience; 8; AUG; 8-2014; 1-11
dc.identifier.uri
http://hdl.handle.net/11336/85837
dc.description.abstract
The blood-brain barrier (BBB) is a tightly regulated interface in the Central Nervous System (CNS) that regulates the exchange of molecules in and out from the brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with the adjacent neurons. Astrocytes are essential for the formation and maintenance of the BBB by providing secreted factors that lead to the adequate association between the cells of the BBB and the formation of strong tight junctions. Under neurological disorders, such as chronic cerebral ischemia, brain trauma, Epilepsy, Alzheimer and Parkinson's Diseases, a disruption of the BBB takes place, involving a lost in the permeability of the barrier and phenotypical changes in both the ECs and astrocytes. In this aspect, it has been established that the process of reactive gliosis is a common feature of astrocytes during BBB disruption, which has a detrimental effect on the barrier function and a subsequent damage in neuronal survival. In this review we discuss the implications of astrocyte functions in the protection of the BBB, and in the development of Parkinson's disease (PD) and related disorders. Additionally, we highlight the current and future strategies in astrocyte protection aimed at the development of restorative therapies for the BBB in pathological conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Research Foundation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ASTROCYTES
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BBB
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ENDOTHELIAL CELLS
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PARKINSON DISEASE
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REACTIVE ASTROGLIOSIS
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-27T21:02:36Z
dc.identifier.eissn
1662-5102
dc.journal.volume
8
dc.journal.number
AUG
dc.journal.pagination
1-11
dc.journal.pais
Suiza
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dc.description.fil
Fil: Cabezas, Ricardo. Pontificia Universidad Javeriana; Colombia
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Fil: Ávila, Marcos. Pontificia Universidad Javeriana; Colombia
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Fil: Gonzalez Santos, Janneth. Pontificia Universidad Javeriana; Colombia
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Fil: El Bachá, Ramon Santos. Universidade Federal da Bahia; Brasil
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Fil: Báez, Eliana. Pontificia Universidad Javeriana; Colombia
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Fil: Garcia Segura, Luis Miguel. Consejo Superior de Investigaciones Científicas; España
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Fil: Coronel, Juan Camilo Jurado. Pontificia Universidad Javeriana; Colombia
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Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
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Fil: Cardona Gomez, Gloria Patricia. Universidad de Antioquia; Colombia
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Fil: Barreto, George E.. Pontificia Universidad Javeriana; Colombia
dc.journal.title
Frontiers in Cellular Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fncel.2014.00211
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fncel.2014.00211/full
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