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dc.contributor.author
Fernandez, Ariel  
dc.date.available
2019-10-11T20:56:34Z  
dc.date.issued
2017-09-04  
dc.identifier.citation
Fernandez, Ariel; Engineering tumor hypersusceptibility to checkpoint immunotherapy; Cell Press; Trends in Cancer; 3; 10; 4-9-2017; 675-677  
dc.identifier.issn
2405-8033  
dc.identifier.uri
http://hdl.handle.net/11336/85814  
dc.description.abstract
The immune checkpoint blockerpembrolizumab(Keytruda)hasproven successful in treating solidtumors harboring a DNA mismatchrepair (MMR) deficiency. We showthat it is possible to generate adrug-promoted phenotype mim-icking the MMR deficiency in solidtumors, and thereby to engineer ageneric hypersusceptibility to Key-truda through drug-induced meta-bolic stress on DNA synthesis. Thepotential of such drug–Keytrudacombinations as universal treat-ments for solid tumors deserves clinical evaluation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Cell Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CHECKPOINT BLOCKADE  
dc.subject
DNA MISMATCH REPAIR  
dc.subject
EPIGENETIC CANCER THERAPY  
dc.subject
IMMUNOTHERAPY  
dc.subject
PHOSPHOINOSITIDE 3-KINASE  
dc.subject
SOLID TUMOR  
dc.subject.classification
Biotecnología relacionada con la Salud  
dc.subject.classification
Biotecnología de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Engineering tumor hypersusceptibility to checkpoint immunotherapy  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-04T17:10:45Z  
dc.journal.volume
3  
dc.journal.number
10  
dc.journal.pagination
675-677  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Missouri  
dc.description.fil
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Collegium Basilea. Institute for Advanced Study; Suiza  
dc.journal.title
Trends in Cancer  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30159-0  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.trecan.2017.08.002  

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