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dc.contributor.author
Fernandez, Ariel  
dc.date.available
2019-10-11T20:48:21Z  
dc.date.issued
2017-07  
dc.identifier.citation
Fernandez, Ariel; Making Targeted Therapy Compatible with Checkpoint Immunotherapy; Elsevier Science London; Trends In Biotechnology; 35; 7; 7-2017; 582-584  
dc.identifier.issn
0167-7799  
dc.identifier.uri
http://hdl.handle.net/11336/85809  
dc.description.abstract
Immune checkpoint blockades induced by antibodies are revolutionizing cancer therapy. Combinations of checkpoint immunotherapies with kinase inhibitors (KIs) are being clinically evaluated as oncogenic mutations arise. Off-target KI cross-reactivity will often compromise synergistic efficacy, with KIs suppressing T-cell functionalities that checkpoint blockers are purportedly boosting. This incompatibility may be removed through molecular optimization.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science London  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Cancer Immunotherapy  
dc.subject
Checkpoint blockade immunotherapy  
dc.subject
Kinase inhibitor  
dc.subject.classification
Biotecnología relacionada con la Salud  
dc.subject.classification
Biotecnología de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Making Targeted Therapy Compatible with Checkpoint Immunotherapy  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-04T17:10:48Z  
dc.journal.volume
35  
dc.journal.number
7  
dc.journal.pagination
582-584  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina  
dc.journal.title
Trends In Biotechnology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167779917300306  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tibtech.2017.02.008  

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