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dc.contributor.author
Rabodoarivelo, Marie Sylvianne
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Imperiale, Belén Rocío
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Andrianiavomikotroka, Rina
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Brandao, Angela
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Kumar, Parveen
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Singh, Sarman
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Ferrazoli, Lucilaine
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Morcillo, Nora
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Rasolofo, Voahangy
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Palomino, Juan Carlos
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Vandamme, Peter
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Martin, Anandi
dc.date.available
2019-10-11T19:15:33Z
dc.date.issued
2015-10
dc.identifier.citation
Rabodoarivelo, Marie Sylvianne; Imperiale, Belén Rocío; Andrianiavomikotroka, Rina; Brandao, Angela; Kumar, Parveen; et al.; Performance of four transport and storage systems for molecular detection of multidrug-resistant tuberculosis; Public Library of Science; Plos One; 10; 10; 10-2015; 1-11
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/85779
dc.description.abstract
Background Detection of drug-resistant tuberculosis is essential for the control of the disease but it is often hampered by the limitation of transport and storage of samples from remote locations to the reference laboratory. We performed a retrospective field study to evaluate the performance of four supports enabling the transport and storage of samples to be used for molecular detection of drug resistance using the GenoType MTBDRplus. Methods Two hundred Mycobacterium tuberculosis strains were selected and spotted on slides, FTA cards, GenoCards, and in ethanol. GenoType MTBDRplus was subsequently performed with the DNA extracted from these supports. Sensitivity and specificity were calculated and compared to the results obtained by drug susceptibility testing. Results For all supports, the overall sensitivity and specificity for detection of resistance to RIF was between 95% and 100%, and for INH between 95% and 98%. Conclusion The four transport and storage supports showed a good sensitivity and specificity for the detection of resistance to RIF and INH in M. tuberculosis strains using the GenoType MTBDRplus. These supports can be maintained at room temperature and could represent an important alternative cost-effective method useful for rapid molecular detection of drugresistant TB in low-resource settings.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GenoType MTBDRplus.
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DRUG RESISTANT M. TUBERCULOSIS
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TRANSPORT AND STORAGE SYSTEM
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MOLECULAR DRUG RESISTANCE DETECTION
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Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Performance of four transport and storage systems for molecular detection of multidrug-resistant tuberculosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-08T12:12:34Z
dc.journal.volume
10
dc.journal.number
10
dc.journal.pagination
1-11
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Rabodoarivelo, Marie Sylvianne. University of Ghent; Bélgica
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Fil: Imperiale, Belén Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital "Dr. Antonio A. Cetrángolo"; Argentina
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Fil: Andrianiavomikotroka, Rina. Institut Pasteur de Madagascar; Madagascar
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Fil: Brandao, Angela. Fundación Oswaldo Cruz; Brasil
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Fil: Kumar, Parveen. All India Institute of Medical Sciences; India
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Fil: Singh, Sarman. All India Institute of Medical Sciences; India
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Fil: Ferrazoli, Lucilaine. Instituto Adolfo Lutz Núcleo de Tuberculose e Micobacteriosis Sao Paulo; Brasil
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Fil: Morcillo, Nora. Provincia de Buenos Aires. Ministerio de Salud. Hospital "Dr. Antonio A. Cetrángolo"; Argentina
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Fil: Rasolofo, Voahangy. Institut Pasteur de Madagascar; Madagascar
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Fil: Palomino, Juan Carlos. University of Ghent; Bélgica
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Fil: Vandamme, Peter. University of Ghent; Bélgica
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Fil: Martin, Anandi. University of Ghent; Bélgica
dc.journal.title
Plos One
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0139382
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139382
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