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dc.contributor.author
Ballicora, Miguel A.
dc.contributor.author
Iglesias, Alberto Alvaro
dc.contributor.author
Preiss, Jack
dc.date.available
2019-10-11T18:43:44Z
dc.date.issued
2004-12
dc.identifier.citation
Ballicora, Miguel A.; Iglesias, Alberto Alvaro; Preiss, Jack; ADP-glucose pyrophosphorylase: A regulatory enzyme for plant starch synthesis; Springer; Photosynthesis Research; 79; 1; 12-2004; 1-24
dc.identifier.issn
0166-8595
dc.identifier.uri
http://hdl.handle.net/11336/85749
dc.description.abstract
In plants, the synthesis of starch occurs by utilizing ADP-glucose as the glucosyl donor for the elongation of α-1,4-glucosidic chains. In photosynthetic bacteria the synthesis of glycogen follows a similar pathway. The first committed step in these pathways is the synthesis of ADP-glucose in a reaction catalyzed by ADP-glucose pyrophosphorylase (ADPG1c PPase). Generally, this enzyme is allosterically regulated by intermediates of the major 1 carbon assimilatory pathway in the respective organism. In oxygenic photosynthesizers, ADPG1c PPase is mainly regulated by 3-phosphoglycerate (activator) and inorganic orthophosphate (inhibitor), interacting in four different patterns. Recent reports have shown that in higher plants, some of the enzymes could also be redox regulated. In eukaryotes, the enzyme is a heterotetramer comprised of two distinct subunits, a catalytic and a modulatory subunit. The latter has been proposed as related to variations in regulation of the enzyme in different plant tissues. Random and site-directed mutagenesis experiments of conserved amino acids revealed important residues for catalysis and regulation. Prediction of the ADPG1c PPase secondary structure suggests that it shares a common folding pattern to other sugar-nucleotide pyrophosphorylases, and they evolved from a common ancestor.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADP-GLUCOSE PYROPHOSPHORYLASE
dc.subject
GLUCOSE-1 PHOSPHATE ADENYLYL TRANSFERASE
dc.subject
GLYCOGEN
dc.subject
POLYSACCHARIDE SYNTHESIS
dc.subject
STARCH
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
ADP-glucose pyrophosphorylase: A regulatory enzyme for plant starch synthesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-10T19:34:16Z
dc.journal.volume
79
dc.journal.number
1
dc.journal.pagination
1-24
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Ballicora, Miguel A.. Michigan State University; Estados Unidos
dc.description.fil
Fil: Iglesias, Alberto Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Preiss, Jack. Michigan State University; Estados Unidos
dc.journal.title
Photosynthesis Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1023/B:PRES.0000011916.67519.58


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