ADP-glucose Pyrophosphorylase; a Regulatory Enzyme for Bacterial Glycogen Synthesis

Abstract

ADP-Glucose Pyrophosphorylase, a Regulatory Enzyme forBacterial Glycogen SynthesisMiguel A. Ballicora,1 Alberto A. Iglesias,2 and Jack Preiss1*Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824,1and Bioquímica Ba´sica de Macromole´culas, Grupo de Enzimologı´a Molecular, Facultad de Bioquı´mica yCiencias Biolo´gicas, Universidad Nacional del Litoral, Santa Fe, Argentina2INTRODUCTION: FUNCTION AND REGULATION OF ADP-Glc PPase INBACTERIA AND IN PLANTS ......................................................................213PHYSIOLOGICAL ROLE..............................................................................214REGULATORY PROPERTIES AND QUATERNARY STRUCTURE OFADP-Glc PPases FROM DIFFERENT SOURCES.........................................214SUBUNIT STRUCTURE OF PLANT ENZYMES ........................................216IDENTIFICATION OF IMPORTANT AMINO ACID RESIDUES...............216PREDICTION OF THE STRUCTURE OF ADP-Glc PPases .........................217CATALYTIC RESIDUES.......................................................................................................221DOMAIN CHARACTERIZATION.................................................................222EVOLUTION OF ADP-Glc PPases.................................................................222ACKNOWLEDGMENTS ...............................................................................223REFERENCES.................................................................................................223