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dc.contributor.author
Petrera, Erina
dc.contributor.author
Joselevich, Maria
dc.contributor.author
Ghini, Alberto Antonio
dc.contributor.author
Burton, Gerardo
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Coto, Celia Esther
dc.date.available
2019-10-10T20:48:05Z
dc.date.issued
2003-09
dc.identifier.citation
Petrera, Erina; Joselevich, Maria; Ghini, Alberto Antonio; Burton, Gerardo; Coto, Celia Esther; Antiherpes virus activities of new 6-19 carbon-bridged steroids and some synthetic precursors; International Medical Press; Antiviral Chemistry & Chemotherapy; 14; 5; 9-2003; 243-248
dc.identifier.issn
0956-3202
dc.identifier.uri
http://hdl.handle.net/11336/85635
dc.description.abstract
Three synthetic 6,19-carbon bridged steroids: 3β,20β -diacetyloxy-5α-chloro-19a(R)-hydroxy-6,19-methanopregnane, 3β,20β-diacetyloxy-5α-chloro-6,19-methanopregnane, 6,19-methanopregn-4-ene-3,20-dione and four synthetic precursors: 3β,20β-diacetyloxy-19-hydroxypregn-5-ene, 3β,20β -diacetyloxy-pregn-5-en-19-al, 3β,20β -diacetyloxy-19(E)-(methoxymethylidene)-pregn-5-ene and 20β -acetyloxy-3β-hydroxy-19(E)-(methoxymethylidene)-pregn-5-ene were tested against herpes virus replication in cell cultures. Several compounds were cytotoxic for stationary cells. Antiviral studies performed with all compounds against HSV-1 indicated a dose-dependent virus susceptibility with selectivity indexes (SI) values in the range 1.7-183.2. Selected compounds were also tested against HSV-2 and the SI values obtained were in the range of 31-273. Attempts to reveal the step of virus multiplication affected by pregnanes were performed with one compound. HSV-1 virus incubation with the compound did not alter the ability of virus particles to infect cells; moreover, neither virus adsorption nor penetration appeared to be affected. The drug must be present during at least the first 7 h of the virus cycle to inhibit more than 90% of virus production. All these results suggest that these novel molecules interfere with an intracellular step of virus multiplication, thus behaving like true antivirals.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
International Medical Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIVIRAL ACTIVITY
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CARBON-BRIDGED STEROIDS
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HERPES VIRUS
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PREGNANES
dc.subject.classification
Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Antiherpes virus activities of new 6-19 carbon-bridged steroids and some synthetic precursors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-27T17:11:18Z
dc.journal.volume
14
dc.journal.number
5
dc.journal.pagination
243-248
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Petrera, Erina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
dc.description.fil
Fil: Joselevich, Maria. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
dc.description.fil
Fil: Ghini, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
dc.description.fil
Fil: Burton, Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
dc.description.fil
Fil: Coto, Celia Esther. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
dc.journal.title
Antiviral Chemistry & Chemotherapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/095632020301400503
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1177/095632020301400503