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Artículo

Open-loop glucose control: Automatic IOB-based super-bolus feature for commercial insulin pumps

Rosales, Nicolás; de Battista, HernánIcon ; Vehí, Josep; Garelli, FabricioIcon
Fecha de publicación: 06/2018
Editorial: Elsevier Science
Revista: Computer Methods And Programs In Biomedicine
ISSN: 0169-2607
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Sistemas de Automatización y Control

Resumen

Background and Objective: Although there has been significant progress towards closed-loop type 1 diabetes mellitus (T1DM) treatments, most diabetic patients still treat this metabolic disorder in an open-loop manner, based on insulin pump therapy (basal and bolus insulin infusion). This paper presents a method for automatic insulin bolus shaping based on insulin-on-board (IOB) as an alternative to conventional bolus dosing. Methods: The methodology presented allows the pump to generate the so-called super-bolus (SB) employing a two-compartment IOB dynamic model. The extra amount of insulin to boost the bolus and the basal cutoff time are computed using the duration of insulin action (DIA). In this way, the pump automatically re-establishes basal insulin when IOB reaches its basal level. Thus, detrimental transients caused by manual or a-priori computations are avoided. Results: The potential of this method is illustrated via in-silico trials over a 30 patients cohort in single meal and single day scenarios. In the first ones, improvements were found (standard treatment vs. automatic SB) both in percentage time in euglycemia (75g meal: 81.9 ± 15.59 vs. 89.51 ± 11.95, ρ ≃ 0; 100g meal: 75.12 ± 18.23 vs. 85.46 ± 14.96, ρ ≃ 0) and time in hypoglecymia (75g meal: 5.92 ± 14.48 vs. 0.97 ± 4.15, ρ=0.008; 100g meal: 9.5 ± 17.02 vs. 1.85 ± 7.05, ρ=0.014). In a single day scenario, considering intra-patient variability, the time in hypoglycemia was reduced (9.57 ± 14.48 vs. 4.21 ± 6.18, ρ=0.028) and improved the time in euglycemia (79.46 ± 17.46 vs. 86.29 ± 11.73, ρ=0.007). Conclusions: The automatic IOB-based SB has the potential of a better performance in comparison with the standard treatment, particularly for high glycemic index meals with high carbohydrate content. Both glucose excursion and time spent in hypoglycemia were reduced.
Palabras clave: DIABETES MANAGEMENT , DURATION OF INSULIN ACTION , GLYCEMIC CONTROL , INSULIN DOSING , INSULIN-ON-BOARD
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/85456
DOI: http://dx.doi.org/10.1016/j.cmpb.2018.03.007
URL: https://www.sciencedirect.com/science/article/pii/S0169260716314146
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Articulos(LEICI)
Articulos de INSTITUTO DE INVESTIGACIONES EN ELECTRONICA, CONTROL Y PROCESAMIENTO DE SEÑALES
Citación
Rosales, Nicolás; de Battista, Hernán; Vehí, Josep; Garelli, Fabricio; Open-loop glucose control: Automatic IOB-based super-bolus feature for commercial insulin pumps; Elsevier Science; Computer Methods And Programs In Biomedicine; 159; 6-2018; 145-158
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