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dc.contributor.author
Marino Repizo, Leonardo  
dc.contributor.author
Goicoechea, Hector Casimiro  
dc.contributor.author
Raba, Julio  
dc.contributor.author
Cerutti, Estela Soledad  
dc.date.available
2019-10-09T15:44:44Z  
dc.date.issued
2018-08  
dc.identifier.citation
Marino Repizo, Leonardo; Goicoechea, Hector Casimiro; Raba, Julio; Cerutti, Estela Soledad; A simple, rapid and novel method based on salting-out assisted liquid–liquid extraction for ochratoxin A determination in beer samples prior to ultra-high-performance liquid chromatography coupled to tandem mass spectrometry; Taylor & Francis; Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment; 35; 8; 8-2018; 1622-1632  
dc.identifier.issn
1944-0049  
dc.identifier.uri
http://hdl.handle.net/11336/85453  
dc.description.abstract
A novel, simple, easy and cheap sample treatment strategy based on salting-out assisted liquid-liquid extraction for ochratoxin A (OTA) ultra-trace analysis in beer samples using ultra-high-performance liquid chromatography-tandem mass spectrometry determination was developed. The factors involved in the efficiency of pre-treatment were studied employing factorial design in the screening phase and the optimal conditions of the significant variables on the analytical response were evaluated using a central composite face-centred design. Consequently, the amount of salt ((NH4)2SO4), together with the volumes of sample, hydrophilic (acetone) and nonpolar (toluene) solvents, and times of vortexing and centrifugation were optimised. Under optimised conditions, the limits of detection and quantification were 0.02 µg l−1 and 0.08 µg l−1 respectively. OTA extraction recovery by SALLE was approximately 90% (0.2 µg l−1). Furthermore, the methodology was in agreement with EU Directive requirements and was successfully applied for analysis of beer samples.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BEER  
dc.subject
OCHRATOXIN A  
dc.subject
SALTING-OUT ASSISTED LIQUID-LIQUID EXTRACTION  
dc.subject
ULTRA-HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY  
dc.subject.classification
Química Analítica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
A simple, rapid and novel method based on salting-out assisted liquid–liquid extraction for ochratoxin A determination in beer samples prior to ultra-high-performance liquid chromatography coupled to tandem mass spectrometry  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-09-27T14:58:19Z  
dc.identifier.eissn
1944-0057  
dc.journal.volume
35  
dc.journal.number
8  
dc.journal.pagination
1622-1632  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Marino Repizo, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina  
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina  
dc.description.fil
Fil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina  
dc.description.fil
Fil: Cerutti, Estela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina  
dc.journal.title
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/19440049.2018.1486045  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/19440049.2018.1486045