Artículo

Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure

Pascuali, Natalia MarisaIcon ; Scotti, LeopoldinaIcon ; Di Pietro, MarianaIcon ; Oubiña, Gonzalo; Bas, Diana EsterIcon ; May, MariaIcon ; Gómez Muñoz, Antonio; Cuasnicu, Patricia SaraIcon ; Cohen, Debora JuanaIcon ; Tesone, MartaIcon ; Abramovich, Dalhia NuritIcon ; Parborell, Maria Fernanda AgustinaIcon
Fecha de publicación: 05/2018
Editorial: Oxford University Press
Revista: Human Reproduction
ISSN: 0268-1161
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Is ceramide-1-phosphate (C1P) an ovarian protective agent during alkylating chemotherapy?Local administration of C1P drastically reduces ovarian damage induced by cyclophosphamide (Cy) via protection of follicular reserve, restoration of hormone levels, inhibition of apoptosis and improvement of stromal vasculature, while protecting fertility, oocyte quality and uterine morphology.
Palabras clave: CHEMOTHERAPY , GONADOTOXICITY , ONCOFERTILITY , OVARIAN RESERVE , SPHINGOLIPIDS
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/85366
URL: https://academic.oup.com/humrep/article/33/5/844/4925330
DOI: http://dx.doi.org/10.1093/humrep/dey045
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Pascuali, Natalia Marisa; Scotti, Leopoldina; Di Pietro, Mariana; Oubiña, Gonzalo; Bas, Diana Ester; et al.; Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure; Oxford University Press; Human Reproduction; 33; 5; 5-2018; 844-859
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