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dc.contributor.author
Podaza, Enrique Arturo
dc.contributor.author
Echarte, Stella Maris
dc.contributor.author
Chisari, Andrea Nancy
dc.date.available
2019-10-03T19:46:10Z
dc.date.issued
2015-01
dc.identifier.citation
Podaza, Enrique Arturo; Echarte, Stella Maris; Chisari, Andrea Nancy; A low maternal protein diet during pregnancy and lactation induce liver offspring damage, in the rat; Austin Publishing Group; Annals of Nutritional Disorders & Therapy; 2; 1020; 1-2015; 1-5
dc.identifier.issn
2381-8891
dc.identifier.uri
http://hdl.handle.net/11336/85165
dc.description.abstract
Pregnancy and fetal development are periods of rapid growth and cell differentiation when mother and offspring are vulnerable to changes. Adverse events during development can be linked to an increased risk for developing metabolic diseases. The aim of this work is study the effect of protein malnutrition during gestation and lactation on liver morphology and physiology. Pregnant Wistar rats of three months of age who were fed a diet containing 8% of proteins, malnourished group (M) or 20% control group (C). The male offspring of mothers M, or male offspring from mothers C were euthanized. Blood was drawn and liver were dissected. Body weights and liver were lower in the M group. Liver damage was observed by increased serum transaminase, cholesterol and triglycerides in liver. At weaning glucose in M rats was significantly lower relative to controls. Serum proteins, albumin and triglycerides, significantly decreased compared to the control. Both glycogen as proteins liver content decreased in the group M with respect to C. We observed inflammation by increasing TNF-α and IL-6. Histology showed a significant liver injury, cellular swelling was observed, hydropic degeneration, characterized by pale cytoplasm as a result of increased volume of water stored in the cells. Conclusion: The lack of protein during development, compromises the integrity of the structural and functional liver, manifested in adulthood.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Austin Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Fetal Programming
dc.subject
Thrifty Phenotype
dc.subject
Low Protein Diet
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Metabolic Syndrome
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Liver Damage
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Non-Alcoholic Fatty Liver
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
A low maternal protein diet during pregnancy and lactation induce liver offspring damage, in the rat
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-20T14:15:11Z
dc.journal.volume
2
dc.journal.number
1020
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva Jersey
dc.description.fil
Fil: Podaza, Enrique Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Echarte, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Química; Argentina
dc.description.fil
Fil: Chisari, Andrea Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Química; Argentina
dc.journal.title
Annals of Nutritional Disorders & Therapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.austinpublishinggroup.com/nutritional-disorders/fulltext/andt-v2-id1020.php


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