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dc.contributor.author
Giraldo, Sara E.
dc.contributor.author
Rincón, Javier
dc.contributor.author
Guerrero, Mario F.
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López, Isabel
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Jiménez, Ignacio
dc.contributor.author
Marder, Nora Mariel
dc.contributor.author
Wasowski, Cristina Lucia N.
dc.contributor.author
Vergel, Nadezdha E.
dc.date.available
2016-11-30T18:24:53Z
dc.date.issued
2013-08
dc.identifier.citation
Giraldo, Sara E.; Rincón, Javier; Guerrero, Mario F.; López, Isabel; Jiménez, Ignacio; et al.; Valepotriate Hydrines Isolated from an Anticonvulsant Fraction of Valeriana pavonii Poepp. & Endl; Colegio Farmaceuticos Provincia de Buenos Aires; Latin American Journal of Pharmacy; 32; 8-2013; 1224-1230
dc.identifier.issn
0326-2383
dc.identifier.uri
http://hdl.handle.net/11336/8514
dc.description.abstract
The present study deals with the isolation and identification of three valepotriate hydrines that are first reported in Valeriana pavonii Poepp. & Endl. (Valerianaceae), which were obtained from a dichloromethane fraction showing anticonvulsant activity in vivo. The isolation and purification of dichloromethane fraction was carried out by chromatographic techniques. The compounds were identified by comparison of their 1H and 13C NMR spectra with previously published data in scientific literature. Maximal electroshock seizure was used as in vivo pharmacological test, additionally in vitro GABA-A/BDZ-binding site studies were performed. Three valepotriate hydrines: valtrate acetoxyhydrine (1), valtrate isovaleroyloxyhydrine (2) and valtrate chlorohydrine (3), were isolated from a dichloromethane fraction that offered 90% protection against crisis-like tonic-clonic seizures in an in vivo pharmacological maximal electroshock seizure (MES) test in mice (35 mg/kg, p.o.). According to an in vitro GABA-A/BDZ binding site test, the mechanism of action for these compounds does not involve binding to the GABA-A receptor. These compounds are reported in this species for the first time. The valepotriate hydrines isolated from V. pavonii could be active metabolites of this species with anticonvulsant properties, however further in vivo an in vitro studies are required. Their molecular mechanisms of action are unrelated to the benzodiazepine binding site of the GABA-A receptor.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Colegio Farmaceuticos Provincia de Buenos Aires
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anticonvulsant
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Gaba a Receptor
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Tonic-Clonic-Epilepsy
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Valeriana
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Valepotriate Hydrines Isolated from an Anticonvulsant Fraction of Valeriana pavonii Poepp. & Endl
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T17:21:31Z
dc.journal.volume
32
dc.journal.pagination
1224-1230
dc.journal.pais
Argentina
dc.description.fil
Fil: Giraldo, Sara E.. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Rincón, Javier. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Guerrero, Mario F.. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: López, Isabel. Universidad de la Laguna; España
dc.description.fil
Fil: Jiménez, Ignacio. Universidad de la Laguna; España
dc.description.fil
Fil: Marder, Nora Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
dc.description.fil
Fil: Wasowski, Cristina Lucia N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
dc.description.fil
Fil: Vergel, Nadezdha E.. Universidad Nacional de Colombia; Colombia
dc.journal.title
Latin American Journal of Pharmacy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=32&num=8
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