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dc.contributor.author
Bouzat, Cecilia Beatriz
dc.contributor.author
Mukhtasimova, Nuriya
dc.date.available
2019-10-03T14:46:07Z
dc.date.issued
2018-08
dc.identifier.citation
Bouzat, Cecilia Beatriz; Mukhtasimova, Nuriya; The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission; Elsevier; Current Opinion in Physiology; 4; 8-2018; 40-48
dc.identifier.issn
2468-8673
dc.identifier.uri
http://hdl.handle.net/11336/85120
dc.description.abstract
The nicotinic acetylcholine receptor (nAChR) has crucial functions at the neuromuscular junction (NMJ). It belongs to the superfamily of pentameric ligand-gated ion channels and has become the stereotype for probing fundamental structures and mechanisms. The nAChR operates as a molecular machine that transduces the binding of nerve-released ACh into an electrical signal that initiates the process of muscle contraction. Its molecular design has been tuned to function as a near perfect on–off switch that responds to ACh with the efficiency and speed required for proper muscle function. Biochemical, biophysical, electrophysiological and structural studies have allowed an integrated description of the muscle nAChR, providing information of its molecular function at the NMJ in health and disease states and guiding rational therapy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
PATCH CLAMP
dc.subject
NICOTINIC RECEPTOR
dc.subject
NEUROMUSCULAR JUNCTION
dc.subject
SYNAPSIS
dc.subject.classification
Biofísica
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-02T19:18:24Z
dc.journal.volume
4
dc.journal.pagination
40-48
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Mukhtasimova, Nuriya. Mayo Clinic; Estados Unidos
dc.journal.title
Current Opinion in Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S2468867318300646
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cophys.2018.04.008
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