Artículo
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
Cebola, Inês; Rodríguez Seguí, Santiago Andrés
; Cho, Candy H. H.; Bessa, José; Rovira, Meritxell; Luengo, Mario; Chhatriwala, Mariya; Berry, Andrew; Ponsa Cobas, Joan; Maestro, Miguel Angel; Jennings, Rachel E.; Pasquali, Lorenzo; Morán, Ignasi; Castro, Natalia; Hanley, Neil A.; Gomez Skarmeta, Jose Luis; Vallier, Ludovic; Ferrer, Jorge
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
05/2015
Editorial:
Nature Publishing Group
Revista:
Nature Cell Biology
ISSN:
1465-7392
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signalling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role for TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas.
Palabras clave:
TEAD
,
YAP
,
PANCREAS
,
DEVELOPMENT
,
HUMAN
,
ENHANCER
,
EPIGENOMICS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Cebola, Inês; Rodríguez Seguí, Santiago Andrés; Cho, Candy H. H.; Bessa, José; Rovira, Meritxell; et al.; TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors; Nature Publishing Group; Nature Cell Biology; 17; 5; 5-2015; 615-626
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