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dc.contributor.author
Pelisch, Federico Gaston
dc.contributor.author
Sonneville, Remi
dc.contributor.author
Pourkarimi, Ehsan
dc.contributor.author
Agostinho, Ana
dc.contributor.author
Blow, J. Julian
dc.contributor.author
Gartner, Anton
dc.contributor.author
Hay, Ronald T.
dc.date.available
2019-10-01T19:02:51Z
dc.date.issued
2014-12
dc.identifier.citation
Pelisch, Federico Gaston; Sonneville, Remi; Pourkarimi, Ehsan; Agostinho, Ana; Blow, J. Julian; et al.; Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans
; Nature Publishing Group; Nature Communications; 5; 12-2014; 1-14
dc.identifier.issn
2041-1723
dc.identifier.uri
http://hdl.handle.net/11336/84961
dc.description.abstract
The small ubiquitin-like modifier (SUMO), initially characterized as a suppressor of a mutation in the gene encoding the centromeric protein MIF2, is involved in many aspects of cell cycle regulation. The dynamics of conjugation and deconjugation and the role of SUMO during the cell cycle remain unexplored. Here we used Caenorhabditis elegans to establish the contribution of SUMO to a timely and accurate cell division. Chromatin-associated SUMO conjugates increase during metaphase but decrease rapidly during anaphase. Accumulation of SUMO conjugates on the metaphase plate and proper chromosome alignment depend on the SUMO E2 conjugating enzyme UBC-9 and SUMO E3 ligase PIASGEI-17. Deconjugation is achieved by the SUMO protease ULP-4 and is crucial for correct progression through the cell cycle. Moreover, ULP-4 is necessary for Aurora BAIR-20 extraction from chromatin and relocation to the spindle mid-zone. Our results show that dynamic SUMO conjugation plays a role in cell cycle progression.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SUMO
dc.subject
MITOSIS
dc.subject
C. ELEGANS
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Biología Celular, Microbiología
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-30T18:51:39Z
dc.journal.volume
5
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Pelisch, Federico Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. University of Dundee; Reino Unido
dc.description.fil
Fil: Sonneville, Remi. University of Dundee; Reino Unido
dc.description.fil
Fil: Pourkarimi, Ehsan. University of Dundee; Reino Unido
dc.description.fil
Fil: Agostinho, Ana. University of Dundee; Reino Unido
dc.description.fil
Fil: Blow, J. Julian. University of Dundee; Reino Unido
dc.description.fil
Fil: Gartner, Anton. University of Dundee; Reino Unido
dc.description.fil
Fil: Hay, Ronald T.. University of Dundee; Reino Unido
dc.journal.title
Nature Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/ncomms6485
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms6485
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