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dc.contributor.author
Medan, Violeta
dc.contributor.author
Preuss, Thomas
dc.date.available
2019-10-01T18:11:06Z
dc.date.issued
2014-04
dc.identifier.citation
Medan, Violeta; Preuss, Thomas; The Mauthner-cell circuit of fish as a model system for startle plasticity; Elsevier; Journal of Physiology; 108; 2-3; 4-2014; 129-140
dc.identifier.issn
0928-4257
dc.identifier.uri
http://hdl.handle.net/11336/84949
dc.description.abstract
The Mauthner-cell (M-cell) system of teleost fish has a long history as an experimental model for addressing a wide range of neurobiological questions. Principles derived from studies on this system have contributed significantly to our understanding at multiple levels, from mechanisms of synaptic transmission and synaptic plasticity to the concepts of a decision neuron that initiates key aspects of the startle behavior. Here we will review recent work that focuses on the neurophysiological and neuropharmacological basis for modifications in the M-cell circuit. After summarizing the main excitatory and inhibitory inputs to the M-cell, we review experiments showing startle response modulation by temperature, social status, and sensory filtering. Although very different in nature, actions of these three sources of modulation converge in the M-cell network. Mechanisms of modulation include altering the excitability of the M-cell itself as well as changes in excitatory and inhibitor drive, highlighting the role of balanced excitation and inhibition for escape decisions. One of the most extensively studied forms of startle plasticity in vertebrates is prepulse inhibition (PPI), a sensorimotor gating phenomenon, which is impaired in several information processing disorders. Finally, we review recent work in the M-cell system which focuses on the cellular mechanisms of PPI and its modulation by serotonin and dopamine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
DOPAMINE
dc.subject
MAUTHNER CELL
dc.subject
PREPULSE INHIBITION
dc.subject
SEROTONIN
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SOCIAL STATUS
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STARTLE RESPONSE
dc.subject
TEMPERATURE
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The Mauthner-cell circuit of fish as a model system for startle plasticity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-30T18:51:33Z
dc.journal.volume
108
dc.journal.number
2-3
dc.journal.pagination
129-140
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Medan, Violeta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Preuss, Thomas. City University Of New York. Hunter College; Estados Unidos
dc.journal.title
Journal of Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jphysparis.2014.07.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928425714000333
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