Artículo
Rhodotorula minuta-mediated bioreduction of 1,2-diketones
Fecha de publicación:
03/2010
Editorial:
Taylor & Francis Ltd
Revista:
Biocatalysis and Biotransformation
ISSN:
1024-2422
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The reduction of cyclic and acyclic 1,2-diketones was investigated by employing whole cells of the yeast Rhodotorula minuta as biocatalyst. The reactions showed a variable degree of regio- and enantioselectivity depending on the nature of the substrate. In the case of cyclic diketones, the reduction afforded a mixture of diastereomeric diols only. The reduction of acyclic diketones allowed production of both the hydroxy ketone and the diol, in a two-step reaction. The first step was highly regio- and stereoselective, affording the hydroxy ketone of (S)-configuration with high enantiomeric excess. After longer reaction times the corresponding (S,S)-diols were obtained in high yield and diastereomeric excess. © 2010 Informa UK Ltd.
Palabras clave:
1,2-DIKETONES
,
BIOREDUCTION
,
RHODOTORULA MINUTA
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Identificadores
Colecciones
Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Monsalve, Leandro Nicolas; Cerruti, Pedro; Galvagno, Miguel Angel; Baldessari, Alicia; Rhodotorula minuta-mediated bioreduction of 1,2-diketones; Taylor & Francis Ltd; Biocatalysis and Biotransformation; 28; 2; 3-2010; 137-143
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