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Artículo

Immunomodulatory effects of chemokines during the early implantation window

Fraccaroli, Laura VirginiaIcon ; Alfieri, Julio ArmandoIcon ; Perez Leiros, ClaudiaIcon ; Ramhorst, Rosanna ElizabethIcon
Fecha de publicación: 06/2009
Editorial: Frontiers in Bioscience
Revista: Frontiers in Bioscience
ISSN: 1093-9946
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Successful implantation requires a functionally normal embryo at the blastocyst stage and a receptive endometrium as well as adequate communication between them throughout the implantation process. This cross-talk is highly regulated by a number of different kinds of molecules. Particularly, chemokines, small polypeptides that attract specific leukocyte subsets by binding to cell-surface receptors, are also required to maintain immune-privileged sites as the feto-maternal interface. Chemokines expression involves an interdependent network with the absence of a single chemokine affecting the expression of multiple other chemokines, we have chosen to focus on just two representative examples: RANTES (regulated on normal T cell expressed and secreted) and MCP-1 (Monocyte chemo-attractant protein). Here, we present updated information on their expression levels and regulation on three different levels: 1) systemic effects on maternal allogeneic response; 2) local effects on endometrial cells; and 3) during an early stage of the feto-maternal dialogue. For each of the three levels, we analyzed data from both fertile women and patients having experienced recurrent spontaneous abortions as representative of physiological and pathological situations respectively.
Palabras clave: Chemokines , Recurrent Spontaneous Abortion , Tolerance , Pregnancy , Review
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/84690
URL: https://www.bioscience.org/fbs/getfile.php?FileName=/2009/v1e/af/28/28.pdf
Colecciones
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Fraccaroli, Laura Virginia; Alfieri, Julio Armando; Perez Leiros, Claudia; Ramhorst, Rosanna Elizabeth; Immunomodulatory effects of chemokines during the early implantation window; Frontiers in Bioscience; Frontiers in Bioscience; 28; 6-2009; 288-298
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