Glucose-regulated protein 78 (Grp78/BiP) is secreted by human oviduct epithelial cells and the recombinant protein modulates sperm-zona pellucida binding

Marin Briggiler, Clara Isabel; González Echeverría, María F.; Munuce, María José; Ghersevich, Sergio Albino; Caille, Adriana M.; Hellman, Ulf; Corrigall, Valerie M.; Vazquez, Monica Hebe

doi:10.1016/j.fertnstert.2008.12.132

Artículo

Glucose-regulated protein 78 (Grp78/BiP) is secreted by human oviduct epithelial cells and the recombinant protein modulates sperm-zona pellucida binding

; González Echeverría, María F.; Munuce, María José; Ghersevich, Sergio Albino; Caille, Adriana M.; Hellman, Ulf; Corrigall, Valerie M.; Vazquez, Monica Hebe Icon

Fecha de publicación: 03/2010

Editorial: Elsevier Science Inc

Revista: Fertility and Sterility

ISSN: 0015-0282

Idioma: Inglés

Tipo de recurso: Artículo publicado

Clasificación temática:

Fisiología

Resumen

To determine the secretion of Grp78 by human oviduct epithelial cells, its association to spermatozoa, and its involvement in gamete interaction. Prospective study. Basic research laboratory. Semen samples obtained from normozoospermic volunteers. Tubal tissue provided by patients undergoing hysterectomies. Oocytes collected from women undergoing IVF-ET. Analysis of Grp78 expression and secretion by oviductal tissue. Gamete incubation with recombinant Grp78 (rec-Grp78).

Palabras clave: BIP , CHAPERONE , GAMETE INTERACTION , GRP78 , OVIDUCT , SPERMATOZOA , ZONA PELLUCIDA

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/84574

URL: https://www.fertstert.org/article/S0015-0282(08)04822-X/fulltext

DOI: http://dx.doi.org/10.1016/j.fertnstert.2008.12.132

Colecciones

Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Citación

Marin Briggiler, Clara Isabel; González Echeverría, María F.; Munuce, María José; Ghersevich, Sergio Albino; Caille, Adriana M.; et al.; Glucose-regulated protein 78 (Grp78/BiP) is secreted by human oviduct epithelial cells and the recombinant protein modulates sperm-zona pellucida binding; Elsevier Science Inc; Fertility and Sterility; 93; 5; 3-2010; 1574-1584

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