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Artículo

Plasticity in the rat prefrontal cortex: linking gene expression and an operant learning with a computational theory

Rapanelli, MaximilianoIcon ; Lew, Sergio Eduardo; Frick, Luciana RominaIcon ; Zanutto, Bonifacio SilvanoIcon
Fecha de publicación: 01/2010
Editorial: Public Library of Science
Revista: Plos One
ISSN: 1932-6203
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología; Otras Matemáticas

Resumen

The plasticity in the medial Prefrontal Cortex (mPFC) of rodents or lateral prefrontal cortex in non human primates (lPFC), plays a key role neural circuits involved in learning and memory. Several genes, like brain-derived neurotrophic factor (BDNF), cAMP response element binding (CREB), Synapsin I, Calcium/calmodulin-dependent protein kinase II (CamKII), activity-regulated cytoskeleton-associated protein (Arc), c-jun and c-fos have been related to plasticity processes. We analysed differential expression of related plasticity genes and immediate early genes in the mPFC of rats during learning an operant conditioning task. Incompletely and completely trained animals were studied because of the distinct events predicted by our computational model at different learning stages. During learning an operant conditioning task, we measured changes in the mRNA levels by Real-Time RT-PCR during learning; expression of these markers associated to plasticity was incremented while learning and such increments began to decline when the task was learned. The plasticity changes in the lPFC during learning predicted by the model matched up with those of the representative gene BDNF. Herein, we showed for the first time that plasticity in the mPFC in rats during learning of an operant conditioning is higher while learning than when the task is learned, using an integrative approach of a computational model and gene expression.
Palabras clave: BEHAVIOR, ANIMAL , MATHEMATICAL MODEL , GENE EXPRESSION , LEARNING
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/84569
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008656
DOI: http://dx.doi.org/10.1371/journal.pone.0008656
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Rapanelli, Maximiliano; Lew, Sergio Eduardo; Frick, Luciana Romina; Zanutto, Bonifacio Silvano; Plasticity in the rat prefrontal cortex: linking gene expression and an operant learning with a computational theory; Public Library of Science; Plos One; 5; 1; 1-2010
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