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dc.contributor.author
Stelitano, Debora
dc.contributor.author
Leticia, Yamila Peche
dc.contributor.author
Dalla, Emiliano
dc.contributor.author
Monte, Martin
dc.contributor.author
Piazza, Silvano
dc.contributor.author
Schneider, Claudio
dc.date.available
2019-09-25T18:02:56Z
dc.date.issued
2017-06
dc.identifier.citation
Stelitano, Debora; Leticia, Yamila Peche; Dalla, Emiliano; Monte, Martin; Piazza, Silvano; et al.; GTSE1: a novel TEAD4-E2F1 target gene involved in cell protrusions formation in triple-negative breast cancer cell models; Impact Journals; Oncotarget; 8; 40; 6-2017; 67422-67438
dc.identifier.issn
1949-2553
dc.identifier.uri
http://hdl.handle.net/11336/84422
dc.description.abstract
Dissemination of cancer cells from the primary tumors to distant organs represents the main cause of death in cancer patients. GTSE1 over-expression has been reported as a potential marker for metastasis in various types of malignancies including breast cancer where GTSE1 expression levels correlate with tumor grade, enhanced invasive potential and negative prognosis. Given the tight correlation between GTSE1 deregulation and bad clinical outcome the aim of this work was to clarify how GTSE1 is regulated in TNBC and the molecular mechanism underlying GTSE1-dependent cell movement. Here, we identified GTSE1 as a novel direct TEAD4 and E2F1 transcription factors target gene highlighting a role for YAP and TAZ co-activators in GTSE1 transcriptional regulation. Frequently deregulated in cancers, TEAD4 and the co-activators YAP and TAZ have been reported to promote tumorigenesis, invasion and metastasis in breast cancer. Here, we demonstrated that the effect of TEAD transcription factor on cell migration and invasion is GTSE1-dependent. Moreover, we found that TEAD controls cell protrusions formation, required for cell migration, through GTSE1 protein unveiling a relevant effector role for GTSE1 in the TEAD-dependent cellular functions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Impact Journals
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Gtse
dc.subject
Triple Negative Breast Cancer
dc.subject
E2f
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
GTSE1: a novel TEAD4-E2F1 target gene involved in cell protrusions formation in triple-negative breast cancer cell models
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-23T17:12:54Z
dc.journal.volume
8
dc.journal.number
40
dc.journal.pagination
67422-67438
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Stelitano, Debora. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie; Italia
dc.description.fil
Fil: Leticia, Yamila Peche. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie; Italia
dc.description.fil
Fil: Dalla, Emiliano. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie; Italia
dc.description.fil
Fil: Monte, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Piazza, Silvano. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie; Italia. University of Trento; Italia
dc.description.fil
Fil: Schneider, Claudio. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie; Italia. Università degli Studi di Udine; Italia
dc.journal.title
Oncotarget
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=18691&path[]=60039
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.18632/oncotarget.18691
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