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Artículo

HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy

Cordo Russo, Rosalia InesIcon ; Piccioni, Flavia ValeriaIcon ; Barrientos, Gabriela LauraIcon ; Mazzolini Rizzo, Guillermo DanielIcon ; Klapp, Burghard F.; Alaniz, Laura DanielaIcon ; García, Mariana GabrielaIcon ; Blois, Sandra M.
Fecha de publicación: 12/2012
Editorial: Research Trends
Revista: Current Trends in Immunology
ISSN: 0972-4567
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Hyaluronan (HA) is a glycosaminoglycan component of the extracellular matrix, where it possesses functions in morphogenesis, tissue injury and repair, inflammation, and tumorigenesis. HA is synthesized by HA synthases (HAS) and is degraded by hyaluronidases (HYAL). Increased levels of HA in tumors, due to differential expression of HAS and HYAL, are related to tumor progression and metastasis. During pregnancy, changes in HA deposition and distribution indicate that HA participates in preparation of the endometrial stroma for reception of the embryo. While pregnancy is a physiological state and cancer a complex and unpredictable pathology, both trophoblast and tumor cells share some proliferative, invasive, and immune tolerance mechanisms that allow establishment of pregnancy and tumor progression. This indicates that the study of a physiological condition such as pregnancy could help to find novel cancer treatment strategies. Abnormal HA metabolism has been observed in cancer and pathologies of pregnancy, thus indicating that HA could be considered a key molecule, able to regulate these processes. This review discusses the role of HA in cancer and pregnancy: the study of similarities and differences between both models could lead to identification of new targets for treatment of tumors or pregnancy-associated pathologies.
Palabras clave: Hyaluronan , Cancer , Pregnancy , Hyaluronidase
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/84226
URL: http://www.researchtrends.net/tia/abstract.asp?in=0&vn=13&tid=36&aid=3642&pub=20
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Cordo Russo, Rosalia Ines; Piccioni, Flavia Valeria; Barrientos, Gabriela Laura; Mazzolini Rizzo, Guillermo Daniel; Klapp, Burghard F.; et al.; HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy ; Research Trends; Current Trends in Immunology; 13; 12-2012; 81-94
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