Artículo
Progesterone reverts LPS-reduced FAAH activity in murine peripheral blood mononuclear cells by a receptor-mediated fashion
Wolfson, Manuel Luis
; Aisemberg, Julieta
; Salazar, Ana Inés
; Domínguez Rubio, Ana Paula
; Vercelli, Claudia Alejandra
; Franchi, Ana Maria
Fecha de publicación:
06/2013
Editorial:
Elsevier Ireland
Revista:
Molecular And Cellular Endocrinology
ISSN:
0303-7207
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Increased anandamide concentrations are associated with pregnancy failure. Anandamide levels are regulated by the fatty acid amide hydrolase (FAAH). The aim of the study was to investigate the role of progesterone (P) on FAAH modulation in murine peripheral blood mononuclear cells (PBMC) under septic conditions. We observed that in vivo administration of LPS to non-pregnant (NP) mice decreased FAAH activity of PBMC while in pregnant mice no changes in FAAH activity were observed. NP animals administered with P had a similar response to LPS as the pregnant animals. Also, NP mice injected with P antagonist and P showed that the effect of P on LPS-reduced FAAH activity was impaired. Furthermore, LPS produced a decrease in the ratio of PR-B/PR-A in NP animals.
Our results showed that, in our model the endotoxin decreased PBMC’s FAAH activity and this condition was reverted by P in a receptor-mediated fashion.
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Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Wolfson, Manuel Luis; Aisemberg, Julieta; Salazar, Ana Inés; Domínguez Rubio, Ana Paula; Vercelli, Claudia Alejandra; et al.; Progesterone reverts LPS-reduced FAAH activity in murine peripheral blood mononuclear cells by a receptor-mediated fashion; Elsevier Ireland; Molecular And Cellular Endocrinology; 381; 1-2; 6-2013; 97-105
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