Artículo
Hb S-São Paulo: A new sickling hemoglobin with stable polymers and decreased oxygen affinity
Jorge, Susan E. D. C.; Petruk, Ariel Alcides
; Kimura, Elza M.; Oliveira, Denise M.; Caire, Lucas; Suemasu, Cintia N.; Silveira, Paulo A. A.; Albuquerque, Dulcineia M.; Costa, Fernando F.; Skaf, Munir S.; Martínez, Leandro; De Fatima Sonati, Maria
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
03/2012
Editorial:
Elsevier Science Inc
Revista:
Archives of Biochemistry and Biophysics
ISSN:
0003-9861
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Hb S-São Paulo (SP) [HBB:c.20A > T p.Glu6Val; c.196A > G p.Lys65Glu] is a new double-mutant hemoglobin that was found in heterozygosis in an 18-month-old Brazilian male with moderate anemia. It behaves like Hb S in acid electrophoresis, isoelectric focusing and solubility testing but shows different behavior in alkaline electrophoresis, cation-exchange HPLC and RP-HPLC. The variant is slightly unstable, showed reduced oxygen affinity and also appeared to form polymers more stable than the Hb S. Molecular dynamics simulation suggests that the polymerization is favored by interfacial electrostatic interactions. This provides a plausible explanation for some of the reported experimental observations
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Citación
Jorge, Susan E. D. C.; Petruk, Ariel Alcides; Kimura, Elza M.; Oliveira, Denise M.; Caire, Lucas; et al.; Hb S-São Paulo: A new sickling hemoglobin with stable polymers and decreased oxygen affinity; Elsevier Science Inc; Archives of Biochemistry and Biophysics; 519; 1; 3-2012; 23-31
Compartir
Altmétricas