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dc.contributor.author
Garcia Gutierrez, María S.
dc.contributor.author
Ortega Alvaro, Antonio
dc.contributor.author
Busquets García, Arnau
dc.contributor.author
Perez Ortiz, José M.
dc.contributor.author
Caltana, Laura Romina
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dc.contributor.author
Ricatti, María Jimena
dc.contributor.author
Brusco, Herminia Alicia
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dc.contributor.author
Maldonado, Rafael
dc.contributor.author
Manzanares, Jorge
dc.date.available
2016-11-24T18:50:49Z
dc.date.issued
2013-05
dc.identifier.citation
Garcia Gutierrez, María S.; Ortega Alvaro, Antonio; Busquets García, Arnau; Perez Ortiz, José M.; Caltana, Laura Romina; et al.; Synaptic plasticity alterations associated to memory impairment induced by deletion of CB2 cannabinoid receptor; Elsevier; Neuropharmacology; 73; 5-2013; 388-396
dc.identifier.issn
0028-3908
dc.identifier.uri
http://hdl.handle.net/11336/8363
dc.description.abstract
In this study, the role of CB2r on aversive memory consolidation was further evaluated. Mice lacking CB2r (CB2KO) and their corresponding littermates (WT) were exposed to the step-down inhibitory avoidance test (SDIA). MAP2, NF200 and synaptophysin (SYN)-immunoreactive fibers were studied in the hippocampus (HIP) of both genotypes. The number of synapses, postsynaptic density thickness and the relation between the synaptic length across the synaptic cleft and the distance between the synaptic ends were evaluated in the HIP (dentate gyrus (DG) and CA1 fields) by electron microscopy. Brainderived neurotrophic factor (BDNF), glucocorticoid receptor (NR3C1) gene expressions and mTOR/ p70S6K signaling cascade were evaluated in the HIP and prefrontal cortex (PFC). Finally, the effects of acute administration of CB2r-agonist JWH133 or CB2r-antagonist AM630 on memory consolidation were evaluated in WT mice by using the SDIA.<br />The lack of CB2r impaired aversive memory consolidation, reduced MAP2, NF200 and SYNimmunoreactive fibers and also reduced the number of synapses in DG of CB2KO mice. BDNF and NR3C1 gene expression were reduced in the HIP of CB2KO mice. An increase of p-p70S6K (T389 and S424) and p-AKT protein expression was observed in the HIP and PFC of CB2KO mice. Interestingly, administration of AM630 impaired aversive memory consolidation, whereas JWH133 enhanced it. Further functional and molecular assessments would have been helpful to further support our conclusions. These results revealed that CB2r are involved in memory consolidation, suggesting that this receptor could be a promising target for developing novel treatments for different cognitive impairmentrelated disorders.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Cb2r
dc.subject
Mice Laking Cb2r
dc.subject
Memory
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Cannabinoid Cb2r-Agonist Jwh133
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Synaptic plasticity alterations associated to memory impairment induced by deletion of CB2 cannabinoid receptor
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T17:21:33Z
dc.journal.volume
73
dc.journal.pagination
388-396
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Garcia Gutierrez, María S.. Consejo Superior de Investigaciones Cientificas; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil
Fil: Ortega Alvaro, Antonio. Universitat Pompeu Fabra; España. Complejo Hospitalario Universitario de Albacete; España
dc.description.fil
Fil: Busquets García, Arnau. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Perez Ortiz, José M.. Complejo Hospitalario Universitario de Albacete; España
dc.description.fil
Fil: Caltana, Laura Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
dc.description.fil
Fil: Ricatti, María Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
dc.description.fil
Fil: Brusco, Herminia Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
dc.description.fil
Fil: Maldonado, Rafael. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Manzanares, Jorge. Consejo Superior de Investigaciones Cientificas; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.journal.title
Neuropharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0028390813002487
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuropharm.2013.05.034
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