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dc.contributor.author
Zhang, Jingming
dc.contributor.author
Lanuza, Guillermo Marcos
dc.contributor.author
Britz, Olivier
dc.contributor.author
Wan, Zhi
dc.contributor.author
Siembad, Valerie C.
dc.contributor.author
Zhang, Ying
dc.contributor.author
Velasquez, Tomoko
dc.contributor.author
Alvarez, Francisco J.
dc.contributor.author
Frank, Eric
dc.contributor.author
Goulding, Martyn
dc.date.available
2016-11-24T17:27:25Z
dc.date.issued
2014-04
dc.identifier.citation
Zhang, Jingming; Lanuza, Guillermo Marcos; Britz, Olivier; Wan, Zhi; Siembad, Valerie C.; et al.; V1 and V2b Interneurons Secure the Alternating Flexor-Extensor Motor Activity Mice Require for Limbed Locomotion; Elsevier; Neuron; 82; 1; 4-2014; 138-150
dc.identifier.issn
0896-6273
dc.identifier.uri
http://hdl.handle.net/11336/8355
dc.description.abstract
Reciprocal activation of flexor and extensor muscles constitutes the fundamental mechanism that tetrapod vertebrates use for locomotion and limbdriven reflex behaviors. This aspect of motor coordination is controlled by inhibitory neurons in the spinal cord; however, the identity of the spinal interneurons that serve this function is not known. Here, we show that the production of an alternating flexor-extensor motor rhythm depends on the composite activities of two classes of ventrally located inhibitory neurons, V1 and V2b interneurons (INs). Abrogating V1 and V2b IN-derived neurotransmission in the isolated spinal cord results in a synchronous pattern of L2 flexor-related and L5 extensor-related locomotor activity. Mice lacking V1 and V2b inhibition are unable to articulate their limb joints and displaymarked deficits in limb-driven reflex movements. Taken together, these findings identify V1- and V2b-derived neurons as the core interneuronal components of the limb central pattern generator (CPG) that coordinate flexor-extensor motor activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Motor System
dc.subject
Spinal Reflex
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Interneuron
dc.subject
Cpg
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
V1 and V2b Interneurons Secure the Alternating Flexor-Extensor Motor Activity Mice Require for Limbed Locomotion
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-18T15:20:15Z
dc.journal.volume
82
dc.journal.number
1
dc.journal.pagination
138-150
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Zhang, Jingming. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.description.fil
Fil: Lanuza, Guillermo Marcos. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.description.fil
Fil: Britz, Olivier. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.description.fil
Fil: Wan, Zhi. Tufts University School of Medicine. Department of Molecular Physiology and Pharmacology; Estados Unidos
dc.description.fil
Fil: Siembad, Valerie C.. Wright State University. Department of Neurosciences, Cell Biology, and Physiology; Estados Unidos
dc.description.fil
Fil: Zhang, Ying. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos. Dalhousie University. Department of Anatomy and Neurobiology; Canadá
dc.description.fil
Fil: Velasquez, Tomoko. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.description.fil
Fil: Alvarez, Francisco J.. Wright State University. Department of Neurosciences, Cell Biology, and Physiology; Estados Unidos. Emory University. Department of Physiology; Estados Unidos
dc.description.fil
Fil: Frank, Eric. Tufts University School of Medicine. Department of Molecular Physiology and Pharmacology; Estados Unidos
dc.description.fil
Fil: Goulding, Martyn. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.journal.title
Neuron
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://www.sciencedirect.com/science/article/pii/S0896627314001111
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuron.2014.02.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096991/


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