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dc.contributor.author Goulding, Martyn
dc.contributor.author Lanuza, Guillermo Marcos
dc.contributor.author Frank, Eric
dc.contributor.author Alvarez, Francisco J
dc.contributor.author Velasquez, Tomoko
dc.contributor.author Zhang, Ying
dc.contributor.author Siembad, Valerie C
dc.contributor.author Wan, Zhi
dc.contributor.author Britz, Olivier
dc.contributor.author Zhang, Jingming
dc.date.available 2016-11-24T17:27:25Z
dc.date.issued 2014-04
dc.identifier.citation Goulding, Martyn; Lanuza, Guillermo Marcos; Frank, Eric; Alvarez, Francisco J; Velasquez, Tomoko; et al.; V1 and V2b Interneurons Secure the Alternating Flexor-Extensor Motor Activity Mice Require for Limbed Locomotion; Cell Press; Neuron; 82; 1; 4-2014; 138-150
dc.identifier.issn 0896-6273
dc.identifier.uri http://hdl.handle.net/11336/8355
dc.description.abstract Reciprocal activation of flexor and extensor muscles constitutes the fundamental mechanism that tetrapod vertebrates use for locomotion and limbdriven reflex behaviors. This aspect of motor coordination is controlled by inhibitory neurons in the spinal cord; however, the identity of the spinal interneurons that serve this function is not known. Here, we show that the production of an alternating flexor-extensor motor rhythm depends on the composite activities of two classes of ventrally located inhibitory neurons, V1 and V2b interneurons (INs). Abrogating V1 and V2b IN-derived neurotransmission in the isolated spinal cord results in a synchronous pattern of L2 flexor-related and L5 extensor-related locomotor activity. Mice lacking V1 and V2b inhibition are unable to articulate their limb joints and displaymarked deficits in limb-driven reflex movements. Taken together, these findings identify V1- and V2b-derived neurons as the core interneuronal components of the limb central pattern generator (CPG) that coordinate flexor-extensor motor activity.
dc.format application/pdf
dc.language.iso eng
dc.publisher Cell Press
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject motor system
dc.subject spinal reflex
dc.subject interneuron
dc.subject CPG
dc.subject.classification Neurociencias
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title V1 and V2b Interneurons Secure the Alternating Flexor-Extensor Motor Activity Mice Require for Limbed Locomotion
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-11-18T15:20:15Z
dc.journal.volume 82
dc.journal.number 1
dc.journal.pagination 138-150
dc.journal.pais Estados Unidos
dc.description.fil Fil: Goulding, Martyn. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.description.fil Fil: Lanuza, Guillermo Marcos. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.description.fil Fil: Frank, Eric. Tufts University School of Medicine. Department of Molecular Physiology and Pharmacology; Estados Unidos
dc.description.fil Fil: Alvarez, Francisco J. Wright State University. Department of Neurosciences, Cell Biology, and Physiology; Estados Unidos. Emory University. Department of Physiology; Estados Unidos
dc.description.fil Fil: Velasquez, Tomoko. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.description.fil Fil: Zhang, Ying. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos. Dalhousie University. Department of Anatomy and Neurobiology; Canadá
dc.description.fil Fil: Siembad, Valerie C. Wright State University. Department of Neurosciences, Cell Biology, and Physiology; Estados Unidos
dc.description.fil Fil: Wan, Zhi. Tufts University School of Medicine. Department of Molecular Physiology and Pharmacology; Estados Unidos
dc.description.fil Fil: Britz, Olivier. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.description.fil Fil: Zhang, Jingming. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos
dc.journal.title Neuron
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://www.sciencedirect.com/science/article/pii/S0896627314001111
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuron.2014.02.013
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096991/


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)