Mostrar el registro sencillo del ítem
dc.contributor.author
Chattopadhyay, Kausik
dc.contributor.author
Ghosh, Tuhin
dc.contributor.author
Pujol, Carlos Alberto
dc.contributor.author
Carlucci, Maria Josefina
dc.contributor.author
Damonte, Elsa Beatriz
dc.contributor.author
Ray, Bimalendu
dc.date.available
2019-09-13T16:14:56Z
dc.date.issued
2008-11
dc.identifier.citation
Chattopadhyay, Kausik; Ghosh, Tuhin; Pujol, Carlos Alberto; Carlucci, Maria Josefina; Damonte, Elsa Beatriz; et al.; Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities; Elsevier Science; International Journal of Biological Macromolecules; 43; 4; 11-2008; 346-351
dc.identifier.issn
0141-8130
dc.identifier.uri
http://hdl.handle.net/11336/83538
dc.description.abstract
In this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50% (IC50) from 1.1 to 27.4 μg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of β-(1 → 3) and α-(1 → 4)-linked-galactopyranosyl residues. This linear galactan contained Gal2Xyl1, Gal2AnGal2, Gal4 and Me-Gal3AnGal2 as oligomeric building subunits. Sulfate group was located at C-4 of (1 → 3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anti-Hsv Activity
dc.subject
Galactan Sulfate
dc.subject
Gracilaria Corticata
dc.subject.classification
Virología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-27T17:56:05Z
dc.journal.volume
43
dc.journal.number
4
dc.journal.pagination
346-351
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Chattopadhyay, Kausik. The University of Burdwan; India
dc.description.fil
Fil: Ghosh, Tuhin. The University of Burdwan; India
dc.description.fil
Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
dc.description.fil
Fil: Carlucci, Maria Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
dc.description.fil
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
dc.description.fil
Fil: Ray, Bimalendu. The University of Burdwan; India
dc.journal.title
International Journal of Biological Macromolecules
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S014181300800158X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.ijbiomac.2008.07.009
Archivos asociados
Tamaño:
319.7Kb
Formato:
PDF