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dc.contributor.author
Slawson, Justin B
dc.contributor.author
Kuklin, Elena A
dc.contributor.author
Mukherjee, Konark
dc.contributor.author
Pírez, Nicolas
dc.contributor.author
Donelson, Nathan C
dc.contributor.author
Griffith, Leslie C
dc.date.available
2016-11-24T15:19:18Z
dc.date.issued
2014-11
dc.identifier.citation
Slawson, Justin B; Kuklin, Elena A; Mukherjee, Konark; Pírez, Nicolas; Donelson, Nathan C; et al.; Regulation of Dopamine Release by CASK-β Modulates Locomotor Initiation in Drosophila melanogaster; Frontiers; Frontiers in Behavioral Neuroscience; 8; 394; 11-2014; 1-11
dc.identifier.issn
1662-5153
dc.identifier.uri
http://hdl.handle.net/11336/8344
dc.description.abstract
CASK is an evolutionarily conserved scaffolding protein that has roles in many cell types. In Drosophila, loss of the entire CASK gene or just the CASK- transcript causes a complex set of adult locomotor defects. In this study, we show that the motor initiation component of this phenotype is due to loss of CASK- in dopaminergic neurons and can be specifically rescued by expression of CASK- within this subset of neurons. Functional imaging demonstrates that mutation of CASK- disrupts coupling of neuronal activity to vesicle fusion. Consistent with this, locomotor initiation can be rescued by artificially driving activity in dopaminergic neurons. The molecular mechanism underlying this role of CASK- in dopaminergic neurons involves interaction with Hsc70-4, a molecular chaperone previously shown to regulate calcium-dependent vesicle fusion. These data suggest that there is a novel CASK- -dependent regulatory complex in dopaminergic neurons that serves to link activity and neurotransmitter release.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Drosophila Melanogaster
dc.subject
Neurotransmitter Release
dc.subject
Cask
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Dopamine
dc.subject.classification
Biología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Regulation of Dopamine Release by CASK-β Modulates Locomotor Initiation in Drosophila melanogaster
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-18T15:20:28Z
dc.journal.volume
8
dc.journal.number
394
dc.journal.pagination
1-11
dc.journal.pais
Suiza
dc.journal.ciudad
Lausanne
dc.description.fil
Fil: Slawson, Justin B. Brandeis University; Estados Unidos
dc.description.fil
Fil: Kuklin, Elena A. Brandeis University; Estados Unidos
dc.description.fil
Fil: Mukherjee, Konark. Brandeis University; Estados Unidos
dc.description.fil
Fil: Pírez, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Brandeis University; Estados Unidos
dc.description.fil
Fil: Donelson, Nathan C. Brandeis University; Estados Unidos
dc.description.fil
Fil: Griffith, Leslie C. Brandeis University; Estados Unidos
dc.journal.title
Frontiers in Behavioral Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fnbeh.2014.00394/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnbeh.2014.00394
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