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dc.contributor.author
Gay, Claudia Carolina
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dc.contributor.author
Maruñak, Silvana
dc.contributor.author
Teibler, Pamela
dc.contributor.author
Leiva, Laura
dc.contributor.author
Acosta, Ofelia Cristina
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dc.date.available
2016-11-24T14:18:22Z
dc.date.issued
2013-03
dc.identifier.citation
Gay, Claudia Carolina; Maruñak, Silvana; Teibler, Pamela; Leiva, Laura; Acosta, Ofelia Cristina; Effect of monospecific antibodies against baltergin in myotoxicity induced by Bothrops alternatus venom from northeast of Argentina. Role of metalloproteinases in muscle damage; Elsevier; Toxicon; 63; 1; 3-2013; 104-111
dc.identifier.issn
0041-0101
dc.identifier.uri
http://hdl.handle.net/11336/8335
dc.description.abstract
Myotoxicity, one of the most relevant local manifestations in envenomation by Bothrops genus, may result from a direct action of myotoxins or be due to an indirect vascular degeneration and ischemia. Baltergin, a snake venom metalloproteinase (SVMP), isolated from Bothrops alternatus venom has been used to obtain monospecific IgG, in order to determine the relative role of toxin in myotoxicity induced by whole venom. Bothrops diporus venom, another medical relevant genus of the northeastern region of Argentina, was also studied. Anti-baltergin IgG was able to neutralize completely the hemorrhagic activity of B. alternatus venom at an antibodies:venom ratio of 30:1 (w:w). However, mice injected with B. diporus venom showed a small spot remaining even at the highest ratio of IgG:venom assayed (50:1; w:w). Specific antibodies were efficient to neutralize the myotoxicity of B. alternatus venom at ratio 30:1 (w:w) but did not neutralize the same effects in B. diporus venom. Anti-baltergin polyclonal antibodies were useful tools for revealing the central role of SVMPs in the development of myotoxicity of B. alternatus venom, as well as, helping to suggest indirectly presence of potent myotoxic phospholipases A2 (PLA2s) in B. diporus venom.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Baltergin
dc.subject
Hemorrhage
dc.subject
Myotoxicity
dc.subject
Svmps
dc.subject
Bothrops Alternatus
dc.subject
Polyclonal Specific Antibodies
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Effect of monospecific antibodies against baltergin in myotoxicity induced by Bothrops alternatus venom from northeast of Argentina. Role of metalloproteinases in muscle damage
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-23T18:17:06Z
dc.journal.volume
63
dc.journal.number
1
dc.journal.pagination
104-111
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Glasgow
dc.description.fil
Fil: Gay, Claudia Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina. Universidad Nacional del Nordeste. Facultad de Cs.veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina
dc.description.fil
Fil: Maruñak, Silvana. Universidad Nacional del Nordeste. Facultad de Cs.veterinarias; Argentina
dc.description.fil
Fil: Teibler, Pamela. Universidad Nacional del Nordeste. Facultad de Cs.veterinarias; Argentina
dc.description.fil
Fil: Leiva, Laura. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina
dc.description.fil
Fil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Cs.veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina
dc.journal.title
Toxicon
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0041010112008264
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.toxicon.2012.11.028
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